acetyl CoA carboxylase

acetyl CoA carboxylase

a biotin-containing enzyme which participates in the synthesis of fatty acids by catalyzing the carboxylation reaction in which acetyl-CoA is converted to malonyl-CoA. It has the important effect of regulating the rate of fatty acid synthesis and is itself influenced in its activity by the local concentration of magnesium, citrate, palmitylcarnitine and ATP and is stimulated by the action of insulin.