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acetyl CoA

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acetyl CoA /ac·e·tyl CoA/ (as´ĕ-til) (as´ĕ-tēl″ ko-a´) acetyl coenzyme A.
acetyl CoA
abbr.
acetyl coenzyme A

acetyl CoA
key intermediate in aerobic intermediary metabolism of carbohydrates, lipids and some amino acids. Allosteric regulator of the activity of the pyruvate dehydrogenase complex and pyruvate carboxylase. Present in low concentrations but with high turnover. Dependent on B-group vitamin, pantothenic acid for structure of coenzyme A.


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[ILLUSTRATION OMITTED] [ILLUSTRATION OMITTED] The glycolytic pathway consists of a sequence of biochemical transformations in which sugar (typically glucose or fructose) is converted to a compound known as acetyl coenzyme A, or acetyl CoA, that enters the TCA cycle, resulting in the formation of a large amount of ATP.
Phosphorylation of both acetyl CoA carboxylase and AMP-activated protein kinase was increased, thus explaining the increase in fatty acid oxidation.
The active ingredient in the cambogia extract is hydroxycitric acid (HCA), which is a powerful inhibitor of ATP citrate lyase, an enzyme that catalyzes the reaction between citrate and Coenzyme A to Acetyl CoA and oxaloacetate.
 
 
 
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