pertussis is rare, any increased mutation in these or other acellular vaccine
immunogens may have serious implications for the efficacy of current vaccines.
Public health agencies in many developed countries began to recommend the acellular vaccine
in the late 1990s.
A study of 2388 children who received the acellular vaccine
found fewer reactions than with the whole-cell vaccine.
The durability of protection with the acellular vaccine
is not as good as with the whole-cell vaccine, but the problem with the whole-cell vaccine was that it was quite reactive," causing local reactions and fevers, she said in an interview.
In the past 10 years, plasma-derived and yeast-derived vaccines against hepatitis B, an acellular vaccine
against pertussis, and three vaccines against Hemophilus influenzae type b (Hib) have been introduced.
Using this model, they found that the acellular vaccine
, whole-cell vaccine, and natural infection all induced comparably high antibody titers.
The five-component acellular vaccine
gave 85 percent protection, while the two-component vaccine gave 58 percent protection.
But in the mid-1990s --shortly after the acellular vaccine
was introduced in 1991--a gradual resurgence began.
Compared with their peers who had received at least one dose of whole cell vaccine, patients who had received only acellular vaccine
had at least a tripling of the risk of acquiring the disease, lead author Maxwell Witt reported at the meeting.
pertussis cases, which began in 2005, and then spiked even higher in 2010, implicated the acellular vaccine
as the cause.
I'm not surprised to hear that the CDC studies found pertussis immunity waned after the fifth childhood acellular vaccine
dose in some 7- to 10-year-olds.
Boostrix is an acellular vaccine
developed with technology that improves safety and effectiveness.