accumulation

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accumulation

A build-up, assembly; the process of accumulating, collecting together.
 
Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.
 
Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.
References in classic literature ?
A high degree of variability is obviously favourable, as freely giving the materials for selection to work on; not that mere individual differences are not amply sufficient, with extreme care, to allow of the accumulation of a large amount of modification in almost any desired direction.
Tulliver, her feeble faculties almost paralyzed by this sudden accumulation of troubles, went backward and forward to the gate to see if the Laceham coach were coming, though it was not yet time.
Under an accumulation of staggerers, no man can be considered a free agent.
With increasing pressure on insurers to identify their accumulations and potential vulnerabilities more accurately, having a better grasp of potential accumulations within their portfolio of risks can be vital to a company's success" Whitaker said.
The new system includes location level data capture capabilities for property and workers compensation lines, supported by new building level data developed by Sanborn that will allow insurers, reinsurers, and brokers to pinpoint risk accumulations within dense urban environments down to the level of a specific 'four-wall' building.
Over-N-Under conveyors provide economical storage, live accumulations and transfer of parts or loads over distances.
At 11 of the sites, they were able to match yearly snow accumulations to the satellite measurements.
Oil companies once thought some oil accumulations too minor to deal with.
All money in tax-sheltered retirement funds is vulnerable to both income and estate taxes, plus penalties for excess accumulations.
A chart in the marketing brochure typically illustrates accumulations over periods of 10 to 30 years with the predictable result: The tax-deferred accumulation significantly exceeds the accumulation of the taxable investment, particularly over longer periods of time.