accumulation

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accumulation

A build-up, assembly; the process of accumulating, collecting together.
 
Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.
 
Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.
References in periodicals archive ?
With a fast-growing global cyber insurance marketplace, and a constantly evolving cyberthreat landscape, insurers must have a robust cyber accumulations framework.
For instance, if a store owner piles the snow in the store parking lot in the course of removing it from the store entrance, the pile of snow becomes an unnatural accumulation.
Guardian Life ULtra Max Gold Accumulation Sales; High Early Cash Value
Keeping production levels high by adding additional satellite fields will lower per-barrel cost and could ultimately extend the economic life of the accumulations beyond that of a single accumulation.
The mortality risk charge guarantees that if the annuitant/ contract holder dies during the accumulation period, the designated beneficiary will receive the greater of the current market value of the annuity or the annuitant's investment in the contract (less any previous withdrawals).
DCMT 1, series 2007-1, accumulation period shortened to one month from two months;
The report divides port accumulation modeling into two distinct dements--the analysis of exposure accumulation and the analysis of cargo vulnerability in the context of natural perils.
Unknown accumulations may result from a variety of factors, such as business travel, attendance at off-site conferences, and the natural tendency for certain industries to interact.
If a corporation has justified an accumulation for future needs by plans never consummated, it must take this into account in determining whether subsequent accumulations are reasonable.
11, 2001, alerted insurers that they didn't have a firm grasp of accumulations in dense urban areas that took into account not only property but also workers' compensation business, and for larger insurers, their different business units and types of products being written.