accumulation


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accumulation

A build-up, assembly; the process of accumulating, collecting together.
 
Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.
 
Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.
References in classic literature ?
If selection consisted merely in separating some very distinct variety, and breeding from it, the principle would be so obvious as hardly to be worth notice; but its importance consists in the great effect produced by the accumulation in one direction, during successive generations, of differences absolutely inappreciable by an uneducated eye--differences which I for one have vainly attempted to appreciate.
Forbes, in a greater depth of water than from 40 to 250 feet; but they are now covered with sea-deposited strata from 800 to 1000 feet in thickness: hence the bed of the sea, on which these shells once lived, must have sunk downwards several hundred feet, to allow of the accumulation of the superincumbent strata.
Then a slice of our neighbours' land will be wanted by us for pasture and tillage, and they will want a slice of ours, if, like ourselves, they exceed the limit of necessity, and give themselves up to the unlimited accumulation of wealth?
Life, although it may only be an accumulation of anguish, is dear to me, and I will defend it.
Tulliver, her feeble faculties almost paralyzed by this sudden accumulation of troubles, went backward and forward to the gate to see if the Laceham coach were coming, though it was not yet time.
Under an accumulation of staggerers, no man can be considered a free agent.
Yet when he at last arrived, the difficulty of applying them, the accumulations of my problem, were brought straight home to me by the beautiful little presence on which what had occurred had as yet, for the eye, dropped neither stain nor shadow.
She was always watching for black and shiny and spirited horses - watching, hoping, despairing, hoping again; always giving chase and sounding her call, upon the meagrest chance of a response, and breaking her heart over the disappointment; always inquiring, always interested in sales-stables and horse accumulations in general.
The horror of being blocked up at Randalls, while her children were at Hartfield, was full in her imagination; and fancying the road to be now just passable for adventurous people, but in a state that admitted no delay, she was eager to have it settled, that her father and Emma should remain at Randalls, while she and her husband set forward instantly through all the possible accumulations of drifted snow that might impede them.
Earnshaw blushed crimson when his cousin made this revelation of his private literary accumulations, and stammered an indignant denial of her accusations.
Immense accumulations of bird-guano gave the sides of Mount Mendif the appearance of calcareous rocks, and there was enough of the deposit there to manure all the lands in the United Kingdom.
The accumulations of a lifetime wasted," continued Mr.