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ACCORD(1) Angioplastie Coronaire, CORvasal & Diltiazem. A trial assessing the effect of direct nitric oxide donors—linsidomine and molsidomine—on angiographic restenosis post balloon angioplasty.
Primary endpoint 6-month death, non-fatal MI and revascularization
Conclusion Angiographic improvement, slightly decreased rate of restenosis
(2) Action to Control Cardiovascular Risk in Diabetes. A trial assessing the effects of tight control of serum glucose, LCL-cholesterol, blood pressure control and therapy treatment intended to increase HDL-C and lower triglycerides, on cardiovascular risk in patients with type 2 diabetes.
Conclusion Tight control of blood pressure and lipid levels do not reduce combined cardiovascular events in adults with diabetes.