accessory cell


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an·ti·gen-·pre·sent·ing cells (APC),

cells that process protein antigens into peptides and present them on their surface in a form that can be recognized by lymphocytes. APCs include Langerhans cells, dendritic cells, macrophages, B cells, and, in humans, activated T cells.
Synonym(s): accessory cell

accessory cell

A macrophage that aids in immune recognition by binding circulating antigens, processing them and presenting them on cell surfaces so that the immune recognition cascade can proceed, which in addition secrete a broad palette of cytokines and biological response modifiers.

Binding of an antigen to a self-cell is essential for T-cell response to an antigen, as the T-cell receptor requires a self-MHC class-II molecule with a bound foreign antigen before it can respond to an antigen.

an·ti·gen-pre·sent·ing cells

(APC) (an'ti-jen-prĕ-zent'ing selz)
Cells that process protein antigens into peptides and present them on their surface in a form that can be recognized by lymphocytes. APCs include Langerhans cells, dendritic cells, macrophages, B cells, and in humans, activated T cells.
Synonym(s): accessory cell.

accessory cell

A monocyte or macrophage that participates in the immune response.
See: antigen-presenting cell; macrophage
See also: cell
References in periodicals archive ?
In the presence of ConA, in vitro T-cell activation requires accessory cells for co-stimulatory signals (Pollard and Landberg 2001).
This simultaneous binding subsequently results in the costimulation and activation of T-cells and accessory cells, enabling the generation of a strong immune response against tumor cells.
One of the receptors for PDGF, PDGFR[eth], is expressed on a number of human cancers and on accessory cells in tumors that are important for sustaining tumor growth.