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accelerated phase

   Also found in: Wikipedia 0.03 sec.
accelerated phase
Oncology A progressive phase of CML characterized by immature, defective WBCs in BM and peripheral blood which is higher in the chronic phase, but less than in the blast phase. See Blast crisis.


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C,, has received the Health Canada approval of Gleevec(x) (imatinib mesylate), an oral therapy for the treatment of chronic myeloid leukemia (CML) in blast crisis, accelerated phase or chronic phase after failure of interferon-alpha therapy (a current standard therapy).
According to Radich, the disease progresses from the chronic phase into an accelerated phase, and then into the blast crisis phase, the terminal phase of the disease during which it has the greatest resistance to treatment.
The accelerated phase of Chediak-Higashi syndrome: an expression of the virus-associated hemophagocytic syndrome?
 
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