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Related to acarbose: metformin, Glucobay, Miglitol


an α-glucosidase inhibitor used to combat hyperglycemia in treatment of type 2 diabetes mellitus.


Glucobay (UK), Prandase (CA), Precose

Pharmacologic class: Alpha-glucosidase inhibitor

Therapeutic class: Hypoglycemic

Pregnancy risk category B


Improves blood glucose control by slowing carbohydrate digestion in intestine and prolonging conversion of carbohydrates to glucose


Tablets: 25 mg, 50 mg, 100 mg

Indications and dosages

Treatment of type 2 (non-insulin-dependent) diabetes mellitus when diet alone doesn't control blood glucose

Adults: Initially, 25 mg P.O. t.i.d. Increase q 4 to 8 weeks as needed until maintenance dosage is reached. Maximum dosage is 100 mg P.O. t.i.d. for adults weighing more than 60 kg (132 lb); 50 mg P.O. t.i.d. for adults weighing 60 kg or less.


• Hypersensitivity to drug

• Renal dysfunction

• Type 1 diabetes mellitus, diabetic ketoacidosis

• GI disease

• Cirrhosis

• Colonic ulcers

• Inflammatory bowel disease

• Intestinal obstruction

• Pregnancy or breastfeeding


Use cautiously in:

• patients receiving concurrent hypoglycemic drugs

• children.


• Give with first bite of patient's three main meals.

• Know that drug prevents breakdown of table sugar (sucrose). Thus, mild hypoglycemia must be corrected with oral glucose (such as D-glucose or dextrose), and severe hypoglycemia may warrant I.V. glucose or glucagon injection.

• Be aware that drug may be used alone or in combination with insulin, metformin, or sulfonylureas (such as glipizide, glyburide, or glimepiride).

Adverse reactions

GI: diarrhea, abdominal pain, flatulence

Metabolic: hypoglycemia (when used with insulin or sulfonylureas)

Other: edema, hypersensitivity reaction (rash)


Drug-drug. Activated charcoal, calcium channel blockers, corticosteroids, digestive enzymes, diuretics, estrogen, hormonal contraceptives, isoniazid, nicotinic acid, phenothiazines, phenytoin, sympathomimetics, thyroid products: decreased therapeutic effect of acarbose

Digoxin: decreased digoxin blood level and reduced therapeutic effect Insulin, sulfonylureas: hypoglycemia

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase: increased levels

Calcium, vitamin B6: decreased levels

Hematocrit: decreased

Patient monitoring

• Monitor patient for hypoglycemia if he's taking drug concurrently with insulin or sulfonylureas.

• Stay alert for hyperglycemia during periods of increased stress.

• Assess GI signs and symptoms to differentiate drug effects from those caused by paralytic ileus.

• Check 1-hour postprandial glucose level to gauge drug's efficacy.

• Monitor liver function test results. Report abnormalities so that dosage adjustments may be made as needed.

Patient teaching

• Inform patient that drug may cause serious interactions with many common medications, so he should tell all prescribers he's taking it.

• Teach patient about other ways to control blood glucose level, such as recommendations regarding diet, exercise, weight reduction, and stress management.

• Stress importance of testing urine and blood glucose regularly.

• Teach patient about signs and symptoms of hypoglycemia. Tell him that although this drug doesn't cause hypoglycemia when used alone, hypoglycemic symptoms may arise if he takes it with other hypoglycemics.

• Urge patient to keep oral glucose on hand to correct mild hypoglycemia; inform him that sugar in candy won't correct hypoglycemia.

• Inform patient that GI symptoms such as flatulence may result from delayed carbohydrate digestion in intestine.

• Advise patient to obtain medical alert identification and to carry or wear it at all times.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.


/acar·bose/ (a´kahr-bōs) an α inhibitor used in treatment of type 2 diabetes mellitus.


A drug, C25H43NO18, that reduces blood glucose levels by inhibiting the breakdown of complex carbohydrates in the intestine and is used to treat type 2 diabetes.


an insulin-control drug.
indications It is prescribed in the treatment of type 2 diabetes mellitus; it slows the digestion of complex carbohydrates and reduces the demand for insulin. The drug is indicated for use with dietary modifications or other medications that treat diabetes in patients whose hyperglycemia is not sufficiently controlled by diet alone.
contraindications It should not be used by patients with diabetic ketoacidosis or intestinal diseases that may impair digestion or absorption. Caution is advised for use in patients with renal dysfunction.
adverse effects The side effects most often reported include flatulence, diarrhea, and abdominal pain. Increased transaminase levels have been reported in patients taking high doses.


An oral hypoglycaemic drug. A brand name is Glucobay.


adjunct treatment to oral hypoglycaemic agents in type 2 diabetes mellitus and to prevent postprandial hypoglycaemia in type 1 diabeties; delays carbohydrate digestion and absorption


n brand name: Precose, Prandase;
drug class: oligosaccharide, glucosidase enzyme inhibitor;
action: inhibits α-glucosidase enzyme in the GI tract to slow the breakdown of carbohydrates to glucose;
uses: a single drug or in combination with others when diet control is ineffective in controlling blood glucose levels such as with type 2 diabetes mellitus.


an alpha-glucosidase inhibitor which reduces postprandial hyperglycemia. It has been used in the management of diabetes mellitus.
References in periodicals archive ?
After six months, metformin was replaced with acarbose in the therapeutic regimen.
Metformin or acarbose is recommended (see IFG section).
In current research, a non-linear mixed-effects model is investigated to determine the impact of acarbose on postprandial glycemia in a single rat after the ingestion of soluble starch.
Group B was started on multivitamin tablet as a placebo along with other hypoglycemic agents namely, metformin, acarbose, sulfonylureas, insulin therapy except pioglitazone.
GLP1RA and SGLT2I use is associated with significant weight loss, as is use of acarbose and metformin.
In this study, we hypothesised that acarbose affects the composition of the ruminal bacterial community and that it decreases the concentration of LPS in the rumen.
Acarbose is a prescription drug that inhibits the alpha-glucosi-dase enzyme in the intestines.
As compared to control rabbits, Acarbose and Glibenclamide decreased Direct bilirubin (DBR), where as Lisinopril and Amlodipine increased it (Pless than0.
Patients on Acarbose alone: We suggest continuing the prescribed dose(s) of Acarbose at Sehar and Iftar.
Diabetes medications included sulfonylureas (43%), insulin (32%), repaglinide (11%), metformm (66%), acarbose (2%), and glitazones (5%).
8 percent for alpha-amylase compared to acarbose and 103.
7 [micro]g/ml, had stronger inhibition than a positive control, acarbose, with an [IC.