With this background, the present study is being done to estimate the insulin sensitivity of a group of patients with clinically suspected and biopsy proven acanthosis nigricans and to compare the insulin sensitivity indices between obese andnon-obese acanthotics
Regardless of location or associated HPV type, these lesions are typically lined by an acanthotic
squamous epithelium with other obvious changes associated with verrucous lesions, which include hypergranulosis, with large, dense, coalescing keratohyaline granules, and occasional koilocytosis.
2 of the cases of Bullous pemphigoid (BP) had hyperkeratotic and acanthotic
epidermis and all cases showed spongiosis with basal cell vacuolation.
Fully developed lesions show pale acanthotic
epidermis and beneath the original cornified layer, recognizable by its basket-wave appearance, the very beginning of formation of a scale-crust can be seen (7).
Filiform type shows an acanthotic
epidermis with the connective tissue stalk comprised of well vascularised, loosely arranged collagen.
Histopathologi-cally, hematoxyline and eosin stained sections re-vealed a lesion composed of acanthotic
, hyperkeratotic squamous cells.
It is characterized by proliferation of dendritic melanocytes scattered throughout the thickness of an acanthotic
and hyperkeratotic surface epithelium.
Seborrheic keratosis has a wide variety of histologic features, and these lesions are classified histologically as one of three types: hyperkeratotic, acanthotic
, and adenoid.
The lesion shows abrupt transition between normal and acanthotic
dysplastic epithelium, which may involve less than 50% of epithelial layer in mild dysplasia and more than 50% of thickness in severe dysplasia.
In contrast, PEH typically shows a relatively uniform, horizontal inferior border and discrete, elongated, acanthotic
rete ridges (Figure 4, B).
The histology of flat condylomas shows acanthotic
epithelium with mildly attenuated rete pegs, dyskeratosis, and koilocytotic atypia in superficial cells.