acanthosis nigricans


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

acanthosis

 [ak″an-tho´sis]
diffuse hypertrophy or thickening of the prickle cell layer of the skin. adj., adj acanthot´ic.
acanthosis ni´gricans diffuse acanthosis with gray, brown, or black pigmentation, chiefly in the axillae and other body folds, occurring in an adult form, often associated with an internal carcinoma (called malignant acanthosis nigricans) and in a benign, nevoid form, more or less generalized. A benign form associated with obesity, which is sometimes due to endocrine disturbance, is called pseudo-acanthosis nigricans. (See Atlas 2, Part E).

ac·an·tho·sis ni·'gri·cans

[MIM*100600]
an eruption of velvety, warty benign growths and hyperpigmentation on the skin of the axillae, neck, anogenital area, and groin; in adults, may be associated with internal malignancy, endocrine disorders (characterized by insulin resistance), or obesity; seen in Type 2 diabetes in adolescents; a benign hereditary type occurs in children.
See also: pseudoacanthosis nigricans.
[L. fr. niger, black]

acanthosis nigricans

(nī′grĭ-kănz′, nĭg′rĭ-)
n.
An eruption of velvety wartlike growths accompanied by hyperpigmentation in the skin of the axillae, neck, anogenital area, and groin, occurring in a benign form in children, but associated with internal malignancy or reticulosis in adults.

acanthosis nigricans

[nē′grikanz′]
a skin disease characterized by hyperpigmented, velvety thickening of the skin, common in the neck, axilla, and groin. There are benign and malignant forms; the latter is most often associated with cancers of the GI tract. See also acanthosis.
enlarge picture
Acanthosis nigricans

acanthosis nigricans

A condition characterised by dark, hyperkeratotic and papillomatous changes of the skin in body folds, including the axilla, groin, umbilicus, neck. It is associated with diabetes and internal malignancy, typically adenocarcinoma, especially of the GI tract and uterus. Treatment of the underlying condition usually results in resolution of the skin lesions.

Forms
• Malignant—associated with cancer (CA), e.g., gastric CA, but also rarely Hodgkin’s disease, or osteosarcoma.
• Inherited.
• Endocrine-related—Associated with pituitary tumours, polycystic ovary syndrome, insulin resistance, obesity.
• Idiopathic.
• Benign acanthosis nigricans (AN).
• AN associated with obesity.
• Syndromic AN.
• Malignant AN.
• Acral AN.
• Unilateral AN.
• Drug-induced AN.
• Mixed AN.

acanthosis nigricans

Dermatology A condition characterized by hyperkeratosis and papillomatosis Forms Malignant–associated with CA–eg, gastric CA, but also rarely Hodgkin's disease, or bone CA; inherited; endocrine–associated with pituitary tumors, polycystic ovary syndrome, insulin resistance, idiopathic

ac·an·tho·sis ni·gri·cans

(ak-an-thō'sis nī'gri-kanz)
An eruption of velvet warty benign growths and hyperpigmentation occurring in the skin of the axillae, neck, anogenital area, and groin; in adults, may be associated with internal malignancy, endocrine disorders, or obesity; a benign type occurs in children.
[L. fr. niger, black]

acanthosis nigricans

Black or brown pigmented warty areas overlying patches of ACANTHOSIS. These occur in the armpits and other body folds and may sometimes be associated with ACROMEGALY, ADDISON'S DISEASE, POLYCYSTIC OVARY, intestinal CANCER or the INSULIN RESISTANCE SYNDROME.

Acanthosis nigricans

A dark brownish or blackish discoloration of the skin related to overweight and high levels of insulin in the blood. Acanthosis nigricans is most likely to develop in the groin or armpits, or around the back of the neck.
Mentioned in: Insulin Resistance

Miescher,

Alfred Guido, Swiss dermatologist, 1877-1961.
Miescher cheilitis - Synonym(s): Melkersson-Rosenthal syndrome
Miescher-Leder syndrome - reddish granulomatous plaques. Synonym(s): granuloma disciformis; necrobiosis maculosa
Miescher I syndrome - benign velvety warty growths. Synonym(s): acanthosis nigricans
Miescher II syndrome - inflammatory granulomas of the lips. Synonym(s): granulomatous cheilitis

acanthosis nigricans 

A rare skin disorder presenting numerous superficial, pigmented papillomatous growths on various parts of the body. Ocular manifestations are primarily papillomatous lesions of the lid margins, which may be so extensive as to cause punctal occlusion, as well as papillary conjunctivitis. Syn. keratosis nigricans.

ac·an·tho·sis ni·gri·cans

(ak-an-thō'sis nī'gri-kanz) [MIM*100600]
Eruption of velvety, warty benign growths and hyperpigmentation on the skin of the axillae, neck, anogenital area, and groin.
[L. fr. niger, black]

acanthosis

an increased thickness of the stratum spinosum, due to either an increased number or hypertrophy of cells.

frictional acanthosis
see acanthosis nigricans (below).
acanthosis nigricans
a skin disease of dogs characterized by hyperpigmentation, lichenification, seborrhea, and alopecia commencing in the axillae and often spreading to involve flexural surfaces of all limbs, and the ventral body. Dachshunds are particularly predisposed to primary acanthosis, often developing the first changes at a young age. Sporadic cases are secondary to systemic disease, endocrinopathies, hypersensitivity reactions and friction in body folds.
References in periodicals archive ?
Acanthosis nigricans as a risk factor for non-insulin dependent diabetes mellitus.
The patients were graded according to acanthosis nigricans severity on a 1-4 scale.
Major Finding: Seventy-one percent of the females had acanthosis nigricans, 75% had a family history of type 2 diabetes mellitus, 71% had a family history of cardiovascular disease, and 87% had a BMI greater than 26 kg/[m.
They include acanthosis nigricans and NLD, both seen in this patient, as well as bullous diabeticorum, diabetic dermopathy, eruptive xanthomas, generalized granuloma annulare, infections (yeast or bacterial), neuropathic foot ulcers, and scleredema.
Acanthosis nigricans: Acanthosis nigricans is a cosmetic condition strongly associated with insulin resistance in which there is darkening of the skin in areas where there are creases such as the neck and arm pits.
Fundoscopic examination, thyroid gland palpation, abdominal examination for hepatomegaly, foot examination, skin examination (for acanthosis nigricans and signs of lipodystrophy at insulin injection sites), and neurologic testing should be done, and signs of diseases that can cause secondary diabetes (eg, hemochromatosis, pancreatic disease) should be assessed.
Metabolic data was available for all children in the study, and the researchers investigated a suite of markers for early metabolic dysfunction, including triglyceride levels and evidence of acanthosis nigricans (AN), a brown to black hyperpigmented skin rash that is a biomarker for developing insulin resistance and hyperinsulinemia.
Skin tags are common with acanthosis nigricans, as well as in obesity in general and with diabetes; they may serve as a clue to the diagnosis.
In some cases we now have no clear way of distinguishing what kind of diabetes someone has based on how they look," she said, adding that acanthosis nigricans, traditionally associated with type 2 diabetes, is now commonly found in overweight patients with type 1 disease as well.
Early in the disease [type 2], they have high insulin levels, which leads to physical symptoms, such as a little fat around the middle and acanthosis nigricans," Dr.
PCOS symptoms include lack of, infrequent or irregular menstrual cycles, infertility, hirsutism or excessive body or facial hair growth, weight gain, obesity, baldness and thinning hair, adult acne, depression, skin tags or teardrop- shaped pieces of skin and acanthosis nigricans or patches of rough brown to black skin.
The patients she would test for glucose intolerance would be those who are obese and those with acanthosis nigricans, which is a common sign in PCOS patients.