acanthosis


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Related to acanthosis: parakeratosis

acanthosis

 [ak″an-tho´sis]
diffuse hypertrophy or thickening of the prickle cell layer of the skin. adj., adj acanthot´ic.
acanthosis ni´gricans diffuse acanthosis with gray, brown, or black pigmentation, chiefly in the axillae and other body folds, occurring in an adult form, often associated with an internal carcinoma (called malignant acanthosis nigricans) and in a benign, nevoid form, more or less generalized. A benign form associated with obesity, which is sometimes due to endocrine disturbance, is called pseudo-acanthosis nigricans. (See Atlas 2, Part E).

ac·an·tho·sis

(ak-an-thō'sis),
An increase in the thickness of the stratum spinosum of the epidermis.
[G. fr. acantho-, thorn + G. -osis, condition]

acanthosis

/ac·an·tho·sis/ (ak″an-tho´sis) diffuse hyperplasia and thickening of the stratum spinosum of the epidermis.acantholyt´ic
acanthosis ni´gricans  diffuse velvety acanthosis with dark pigmentation, chiefly in the axillae; it occurs in an adult form, often associated with an internal carcinoma (malignant a. nigricans), and in a benign, nevoid form, more or less generalized. A benign juvenile form associated with obesity, which is sometimes due to endocrine disturbance, is called pseudoacanthosis nigricans.

acanthosis

[ak′ənthō′sis]
Etymology: Gk, akantha + osis, condition
an abnormal, diffuse hypertrophy of the stratum spinosum, as in eczema and psoriasis. See also acanthosis nigricans. acanthotic, adj.

acanthosis

Hyperplasia of the squamous epithelium of mucocutaneous surfaces.
Diseases with
Psoriasis, granulomatous reactions, lymphocytic infiltrates.

Mechanism
Defective epidermal cell kinetics.

ac·an·tho·sis

(ak-an-thō'sis)
An increase in the thickness of the stratum spinosum of the epidermis.
[G. fr. acantho-, thorn + G. -osis, condition]

acanthosis

A disease process in the skin featuring overgrowth and thickening of the prickle-cell layer of the EPIDERMIS. This layer lies above its parent layer, the BASAL cell layer, and local overgrowth results in raised, roughened areas such as warts or the lesions of PSORIASIS or ECZEMA.

acanthosis

increase in epidermal stratum spinosum thickness, characteristic of verrucae

ac·an·tho·sis

(ak-an-thō'sis)
Increased thickness of epidermal stratum spinosum.
[G. fr. acantho-, thorn + G. -osis, condition]

acanthosis (ak´ənthō´sis),

n an increase in the number of cells in the prickle cell layer of stratified squamous epithelium, with thickening of the entire epithelial cell layer and a broadening and fusing of rete pegs.

acanthosis

an increased thickness of the stratum spinosum, due to either an increased number or hypertrophy of cells.

frictional acanthosis
see acanthosis nigricans (below).
acanthosis nigricans
a skin disease of dogs characterized by hyperpigmentation, lichenification, seborrhea, and alopecia commencing in the axillae and often spreading to involve flexural surfaces of all limbs, and the ventral body. Dachshunds are particularly predisposed to primary acanthosis, often developing the first changes at a young age. Sporadic cases are secondary to systemic disease, endocrinopathies, hypersensitivity reactions and friction in body folds.
References in periodicals archive ?
Acanthosis nigricans: Acanthosis nigricans is a cosmetic condition strongly associated with insulin resistance in which there is darkening of the skin in areas where there are creases such as the neck and arm pits.
Three-fourths of the patients had acne, nearly all had hirsutism, and more than half (57%) had acanthosis nigricans, signaling insulin resistance.
Although children may be screened for insulin resistance on the basis of clinical features such as obesity, acanthosis nigricans, and family history, identification of the metabolic correlates of insulin resistance requires laboratory assessment.
On examination, she was obese with acanthosis nigricans and tender cervical lymphadenopathy.
Children registered in the Allegheny County Registry for diabetes and the Children's Hospital Registry who have characteristics of both type 1 diabetes (antibodies and/or ketones and diabetic ketoacidosis, for instance) and type 2 diabetes (obesity and/or acanthosis nigricans) are being treated in their communities with either insulin alone or insulin and an oral agent, mainly metformin, she said.
Microscopic evaluation, to confirm the diagnosis, shows varying degrees of hyperkeratosis, acanthosis, and parakeratosis accompanied by a diffuse infiltration of large vacuolated pale staining cells, often with a bluish cytoplasm predominantly found in the lower layers of the epidermis; they can also be present in the epithelium of the underlying adnexal structures.
Surface keratinization (hyperkeratosis), papillomatosis (papillary projections), or acanthosis (wide rete pegs) are common features of seborrheic keratosis.
The most common signs and symptoms that women with PCOS present with include menstrual irregularity, hirsutism, acne, acanthosis nigricans, infertility, obesity, and increased risk of cardiovascular disease.
In this study, melanomas harboring BRAF mutations showed distinct histologic features: increased pagetoid migration, nesting of intraepidermal melanocytes, epidermal acanthosis, and sharper circumscription of the surrounding skin.
Metabolic data was available for all children in the study, and the researchers investigated a suite of markers for early metabolic dysfunction, including triglyceride levels and evidence of acanthosis nigricans (AN), a brown to black hyperpigmented skin rash that is a biomarker for developing insulin resistance and hyperinsulinemia.
In some cases we now have no clear way of distinguishing what kind of diabetes someone has based on how they look," she said, adding that acanthosis nigricans, traditionally associated with type 2 diabetes, is now commonly found in overweight patients with type 1 disease as well.
Pathology of the skin identified acanthosis and parakeratosis.