According to a review of more than 150 elderly patients in the outpatient setting who presented with a chief complaint of persistent pruritus, the five most common diagnoses were atopiclike dermatosis, lichen simplex chronicus/prurigo nodularis, subacute prurigo, transient acantholytic dermatosis
, and neuropathic disease.
Transient acantholytic dermatosis is a self-limited, primary, nonfamilial, non-immune-mediated acantholytic skin disorder that manifests as pruritic, discrete, edematous papules and/or a vesiculopapular rash and is more commonly referred to as Grover disease, after Dr Ralph Grover, who first reported the condition in 1970.
As mentioned previously, although the alternative term transient acantholytic dermatosis is synonymous with Grover disease, the duration of disease may actually extend for many months, and reports of chronic relapsing disease are not an uncommon occurrence.
The association of transient acantholytic dermatosis with other skin diseases.
Incidence of transient acantholytic dermatosis (Grover's disease) in a hospital setting.
Transient acantholytic dermatosis induced by recombinant human interleukin 4.
Transient acantholytic dermatosis (Grover's disease) in a patient with progressive systemic sclerosis treated with D-penicillamine.
Immunofluorescence studies in transient acantholytic dermatosis (Grover's disease).