acantholysis

acantholysis /acan·thol·y·sis/ (ak″an-thol´ĭ-sis) dissolution of the intercellular bridges of the stratum spinosum of the epidermis.acantholyt´ic

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ac·an·thol·y·sis (kn-thl-ss, kn-)

n. pl. ac·an·thol·y·ses (-sz)

Separation of individual prickle cells from their neighbors, as in keratosis follicularis.

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acantholysis (ak´anthol´isis),

n the loosening, separation, or disassociation of individual prickle cells within the epithelium from their neighbor, often seen in conditions such as pemphigus vulgaris and keratosis follicularis.

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acantholysis

loss of cohesion between the epidermal cells, resulting in intraepidermal clefts, vesicles and bullae. Seen in inflammatory, viral and autoimmune skin diseases, particularly the pemphigus complex.

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acantholysis bullosa

see epidermolysis bullosa.

familial acantholysis

a congenital disease of Aberdeen Angus calves characterized by ulceration of the oral mucosa and the skin over the distal limb joints and the coronet.

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acantholysis

Dermatology The pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesicles Diseases with Pemphigus vulgaris, benign familial pemphigus (Hailey-Hailey disease), Darier's disease, staphylococcal scalded-skin syndrome. See Pemphigus vulgaris, Tombstone appearance.