acantholysis


Also found in: Dictionary, Thesaurus.
Related to acantholysis: pemphigus, acanthosis, dyskeratosis, spongiosis, pemphigus vulgaris, bullous pemphigoid

acantholysis

 [ak″an-thol´ĭ-sis]
disruption of the intercellular connections between keratinocytes of the epidermis, caused by lysis of intercellular cement substance. It is associated with the formation of epidermal vesicles in such conditions as pemphigus vulgaris, pemphigus foliaceus, and other skin disorders.

ac·an·thol·y·sis

(ak-an-thol'i-sis), Avoid the mispronunciation acantholy'sis.
Separation of individual epidermal keratinocytes from their neighbor, as in conditions such as pemphigus vulgaris and Darier disease.
[acantho- + G. lysis, loosening]

acantholysis

/acan·thol·y·sis/ (ak″an-thol´ĭ-sis) dissolution of the intercellular bridges of the stratum spinosum of the epidermis.acantholyt´ic

acantholysis

A histologically defined condition characterised by a pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesication and/or separation of the epithelium from the subjacent dermis.

Acantholysis is a misnomer that is retained because it paraphrases a process that cannot be fully defined at the molecular level. It has been applied to a variety of unrelated conditions that share the loss of intraepidermal cohesion, including those in which the loss is clearly the consequence of severe cell damage.

acantholysis

Dermatology The pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesicles Diseases with Pemphigus vulgaris, benign familial pemphigus (Hailey-Hailey disease), Darier's disease, staphylococcal scalded-skin syndrome. See Pemphigus vulgaris, Tombstone appearance.

ac·an·thol·y·sis

(ak'an-thol'i-sis)
Separation of individual epidermal keratinocytes from their neighbors, as in conditions such as pemphigus vulgaris and Darier disease.
[acantho- + G. lysis, loosening]

acantholysis

Splitting apart of layers of cells in the epidermis often top form a blister.

acantholysis

atrophy or detachment of the epidermal stratum spinosum, with intraepidermal blistering

ac·an·thol·y·sis

(ak'an-thol'i-sis)
Separation of individual epidermal keratinocytes from their neighbors.
[acantho- + G. lysis, loosening]

acantholysis (ak´anthol´isis),

n the loosening, separation, or disassociation of individual prickle cells within the epithelium from their neighbor, often seen in conditions such as pemphigus vulgaris and keratosis follicularis.

acantholysis

loss of cohesion between the epidermal cells, resulting in intraepidermal clefts, vesicles and bullae. Seen in inflammatory, viral and autoimmune skin diseases, particularly the pemphigus complex.

acantholysis bullosa
see epidermolysis bullosa.
familial acantholysis
a congenital disease of Aberdeen Angus calves characterized by ulceration of the oral mucosa and the skin over the distal limb joints and the coronet.
References in periodicals archive ?
Immunohistochemistry for IgG4 exhibited a higher sensitivity in pemphigus cases with active acantholysis.
When histopathology shows acantholysis suspicious for pemphigus, often no frozen tissue is available to confirm the diagnosis in such cases.
Acantholytic dyskeratosis is characterized by suprabasilar clefts, acantholysis and dyskeratosis within the epidermis, orthokeratosis, and parakeratosis.
Acantholytic dyskeratosis is characterized by the following changes within the epidermis: suprabasilar clefts, acantholysis, dyskeratosis, orthokeratosis, and parakeratosis.
Orlov MD, Chernyavsky Al, Arredondo J, Grando SA: Synergistic actions of pemphigus vulgaris IgG, Fas-ligand and tumor necrosis factor- during induction of basal cell shrinkage and acantholysis.
Histologically, the acantholysis seen in Grover disease occurs in a variety of different patterns in small, circumscribed foci resembling Darier-White disease, pemphigus vulgaris, pemphigus foliaceous, Hailey-Hailey disease, and a spongiotic dermatitis.
The Darier-like pattern consists of suprabasal acantholysis of keratinocytes with scattered apoptotic or dyskeratotic cells within various levels of the epidermis (Figure 2).
Altered desmosomal plaque proteins within the acantholysis or spongiosis in the acrosyringium has been recognized in Grover disease, further supporting an eccrine contribution.
The epithelial nests displayed focal acantholysis and lacked any significant cytologic atypia (Figure 2).