acantholysis

acantholysis /acan·thol·y·sis/ (ak″an-thol´ĭ-sis) dissolution of the intercellular bridges of the stratum spinosum of the epidermis.acantholyt´ic

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ac·an·thol·y·sis (kn-thl-ss, kn-)

n. pl. ac·an·thol·y·ses (-sz)

Separation of individual prickle cells from their neighbors, as in keratosis follicularis.

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acantholysis [ak″an-thol´ĭ-sis]

disruption of the intercellular connections between keratinocytes of the epidermis, caused by lysis of intercellular cement substance. It is associated with the formation of epidermal vesicles in such conditions as pemphigus vulgaris, pemphigus foliaceus, and other skin disorders.

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acantholysis (ak´anthol´isis),

n the loosening, separation, or disassociation of individual prickle cells within the epithelium from their neighbor, often seen in conditions such as pemphigus vulgaris and keratosis follicularis.

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acantholysis

loss of cohesion between the epidermal cells, resulting in intraepidermal clefts, vesicles and bullae. Seen in inflammatory, viral and autoimmune skin diseases, particularly the pemphigus complex.

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acantholysis bullosa

see epidermolysis bullosa.

familial acantholysis

a congenital disease of Aberdeen Angus calves characterized by ulceration of the oral mucosa and the skin over the distal limb joints and the coronet.

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acantholysis

Dermatology The pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesicles Diseases with Pemphigus vulgaris, benign familial pemphigus (Hailey-Hailey disease), Darier's disease, staphylococcal scalded-skin syndrome. See Pemphigus vulgaris, Tombstone appearance.