acantholysis


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acantholysis

 [ak″an-thol´ĭ-sis]
disruption of the intercellular connections between keratinocytes of the epidermis, caused by lysis of intercellular cement substance. It is associated with the formation of epidermal vesicles in such conditions as pemphigus vulgaris, pemphigus foliaceus, and other skin disorders.

ac·an·thol·y·sis

(ak-an-thol'i-sis), Avoid the mispronunciation acantholy'sis.
Separation of individual epidermal keratinocytes from their neighbor, as in conditions such as pemphigus vulgaris and Darier disease.
[acantho- + G. lysis, loosening]

acantholysis

/acan·thol·y·sis/ (ak″an-thol´ĭ-sis) dissolution of the intercellular bridges of the stratum spinosum of the epidermis.acantholyt´ic

acantholysis

A histologically defined condition characterised by a pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesication and/or separation of the epithelium from the subjacent dermis.

Acantholysis is a misnomer that is retained because it paraphrases a process that cannot be fully defined at the molecular level. It has been applied to a variety of unrelated conditions that share the loss of intraepidermal cohesion, including those in which the loss is clearly the consequence of severe cell damage.

acantholysis

Dermatology The pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesicles Diseases with Pemphigus vulgaris, benign familial pemphigus (Hailey-Hailey disease), Darier's disease, staphylococcal scalded-skin syndrome. See Pemphigus vulgaris, Tombstone appearance.

ac·an·thol·y·sis

(ak'an-thol'i-sis)
Separation of individual epidermal keratinocytes from their neighbors, as in conditions such as pemphigus vulgaris and Darier disease.
[acantho- + G. lysis, loosening]

acantholysis

Splitting apart of layers of cells in the epidermis often top form a blister.

acantholysis

atrophy or detachment of the epidermal stratum spinosum, with intraepidermal blistering

ac·an·thol·y·sis

(ak'an-thol'i-sis)
Separation of individual epidermal keratinocytes from their neighbors.
[acantho- + G. lysis, loosening]

acantholysis (ak´anthol´isis),

n the loosening, separation, or disassociation of individual prickle cells within the epithelium from their neighbor, often seen in conditions such as pemphigus vulgaris and keratosis follicularis.

acantholysis

loss of cohesion between the epidermal cells, resulting in intraepidermal clefts, vesicles and bullae. Seen in inflammatory, viral and autoimmune skin diseases, particularly the pemphigus complex.

acantholysis bullosa
see epidermolysis bullosa.
familial acantholysis
a congenital disease of Aberdeen Angus calves characterized by ulceration of the oral mucosa and the skin over the distal limb joints and the coronet.
References in periodicals archive ?
A definitive diagnosis of PV is made when Nikolsky's sign is positive, in the presence of acantholysis in histopathology and by direct immunofluorescence [2].
Histopathological examination showed intra epithelial split and acantholysis.
Chernyavsky Al, Arredondo J, Piser T, Karlsson E, Grando SA: Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis.
The adhesion between keratinocytes then deteriorates, affecting the desmosomal/keratin filament complex and triggering acantholysis and clinical vesicular changes, blisters, and plaques.
Suprabasilar acantholysis was focally found within the epithelium of a portion of the infundibulum of the central cystic structure (Fig.
Bystryn JC, Grando SA: A novel explanation for acantholysis in pemphigus vulgaris: the basal cell shrinkage hypothesis.
Histopathological examination revealed suprabasal blister formation (Fig-7) associated with extensive acantholysis of keratinocytes, some areas showed prevesicular edema and appear to weaken the junction and the intercellular bridges between the epithelial cells were missing and a final diagnosis of Pemphigus vulgaris was made.
Marked acantholysis associated with Dermatophytosis due to Trichophyton equinum in two horses.
Signs of the classic HSV cytopathic effect included the presence of intracellular proteinaceous fluid, ballooning degeneration of epithelial cells, and acantholysis (figure 2, A) as well as intranuclear inclusion bodies and a ground-glass appearance of some nuclei (figure 2, B).
Skin biopsy reveals intraepidermal bulla or acantholysis in the upper epidermis.
Other areas of the palpebral conjunctivae and skin showed inflammatory foci in the epithelium without ulcer formation but with ballooning degeneration of epithelial cells, acantholysis, and occasional cell necrosis.
2) They are histologically characterized by suprabasilar acantholysis and immunopathologically characterized by autoantibodies to desmosomal cadherins.