abzyme


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cat·a·lyt·ic an·ti·bod·y

an antibody that has been altered to give it a catalytic activity.
Synonym(s): abzyme

Abzyme

Any of a number of hybrid catalytic molecules with antibody-like specificity. The hybrid is generated by combining an antibody with an enzyme; the “ab-” portion corresponds to the highly specific binding sequence, analogous to an immunoglobulin’s variable region, and the “-zyme” portion incorporates catalytic machinery. While most abzymes are synthetic and typically the antibody component is raised against a transition state analogue for the reaction to be catalysed, they may also occur in autoimmune disease, especially systemic lupus erythematosus.

abzyme

An antibody that has an enzyme-like (catalytic) action.

abzyme

a catalytic ANTIBODY, with variable regions possessing enzyme activity. An abzyme is capable of catalysing a chemical reaction by binding to and stabilizing the transition state intermediate.
References in periodicals archive ?
Unlike traditional antibodies that neutralize the target on a 1:1 basis, abzymes are significantly more efficacious because each abzyme molecule can neutralize thousands of target molecules.
Paul's team because his approach using abzymes shows enormous progress in creating an HIV vaccine," said Alan Kleiman, chairman of the board for the Abzyme Research Foundation.
org or call Zachary Barnett at the Abzyme Research Foundation at 347-967-9734 or via email at Zachary@abzymeresearchfoundation.
The Abzyme Research Foundation (ARF) is a non-profit entity established to support innovative research and development for treatment and prevention of HIV/AIDS.
To make an abzyme that specifically cleaves phenylacetate, the researchers obtained antibodies that bind to another longer-lived molecule that is similar in form to phenylacetate's fleeting transition-state.
Since all antibodies are structurally similar, the scientists expect that their success at getting the phenylacetate-cleaving abzyme to work in a reverse micelle will extend to other abzymes.
Now a team of six scientists has coaxed abzymes into doing something new -- work in a greasy, organic environment that normally would deactivate them.
Dismissing the claims of a few scientists, Lerner for years answered that there was no compelling evidence to support the existence of natural abzymes.