Unlike traditional antibodies that neutralize the target on a 1:1 basis, abzymes are significantly more efficacious because each abzyme molecule can neutralize thousands of target molecules.
Paul's team because his approach using abzymes shows enormous progress in creating an HIV vaccine," said Alan Kleiman, chairman of the board for the Abzyme Research Foundation.
org or call Zachary Barnett at the Abzyme Research Foundation at 347-967-9734 or via email at Zachary@abzymeresearchfoundation.
The Abzyme Research Foundation (ARF) is a non-profit entity established to support innovative research and development for treatment and prevention of HIV/AIDS.
To make an abzyme that specifically cleaves phenylacetate, the researchers obtained antibodies that bind to another longer-lived molecule that is similar in form to phenylacetate's fleeting transition-state.
Since all antibodies are structurally similar, the scientists expect that their success at getting the phenylacetate-cleaving abzyme to work in a reverse micelle will extend to other abzymes.
Now a team of six scientists has coaxed abzymes into doing something new -- work in a greasy, organic environment that normally would deactivate them.
Dismissing the claims of a few scientists, Lerner for years answered that there was no compelling evidence to support the existence of natural abzymes