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absolute neutrophil count

   Also found in: Dictionary/thesaurus, Acronyms, Wikipedia, Hutchinson 0.04 sec.
absolute neutrophil count (ANC),
the number of neutrophils in a milliliter of blood, having a reference value of approximately 1500-7700 per μL. The ANC is a measure of a person's immune status. Generally, if the count is above 1000, the person may safely mingle with other people or undergo chemotherapy, but a count below 500 indicates that a person is at high risk for infection and should be kept away from those with infectious diseases. Neutropenia by definition is an ANC below 1800/mm3. It is calculated by adding the number of segmented neutrophils and the number of basal neutrophils and multiplying the sum by the total white blood cell (WBC) count. The formula is ANC = Total WBC count × (% neutrophils + % bands)/100.


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When we used the logistic regression model for univariate analysis, age, underlying disease (nonfatal versus ultimately or rapidly fatal), initial CRP level, initial absolute neutrophil count (ANC), peak CK level, and peak CRP level were predictors of death.
The most common grade 3 or greater toxicities observed in the treatment arms (ERBITUX plus FOLFIRI, ERBITUX plus FOLFOX, FOLFIRI alone, or FOLFOX alone) were diarrhea (22%, 14%, 15%, and 10%, respectively) and absolute neutrophil count (34%, 38%, 27%, and 36%, respectively).
Prescribing health care practitioners, dispensing pharmacists and FazaClo patients must be registered in the FazaClo Patient Registry, which will compare patient information against the National Non-Rechallenge Masterfile and maintain a continuing record of total white blood cell (WBC) counts and absolute neutrophil count (ANC) values and related information for all patients who receive the FazaClo brand of clozapine.
 
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