absolute neutrophil count


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Related to absolute neutrophil count: neutropenia

absolute neutrophil count (ANC)

the number of neutrophils in a milliliter of blood, having a reference value of approximately 1500-7700 per μL. The ANC is a measure of a person's immune status. Generally, if the count is above 1000, the person may safely mingle with other people or undergo chemotherapy, but a count below 500 indicates that a person is at high risk for infection and should be kept away from those with infectious diseases. Neutropenia by definition is an ANC below 1800/mm3. It is calculated by adding the number of segmented neutrophils and the number of basal neutrophils and multiplying the sum by the total white blood cell (WBC) count. The formula is ANC = Total WBC count × (% neutrophils + % bands)/100. Also called the absolute granulocyte count (AGC).

absolute neutrophil count

Abbreviation: ANC
The actual number of neutrophils in a cubic millimeter of blood. The approximate normal range is 3000 to 6000 cells/mm3. This figure is measured before and after drugs are given that may lower neutrophil counts, such as those used in cancer chemotherapy. Generally, chemotherapy is not given unless the patient's ANC is greater than 1000. Patients with an ANC of less than 500 cells/mm3 are at high risk for infection. See: neutrophil

CAUTION!

The development of fever in a patient with neutropenia secondary to chemotherapy is an indication for urgent medical evaluation and prompt institution of broad-spectrum antibiotics.
See also: count
References in periodicals archive ?
Cortisone stimulation test (5 mg/kg IV): The absolute neutrophil count is measured every hour for 6 hours.
Table 2: Absolute Neutrophil count (ANC) (n A- 109/l) at day 1 at 3 months and 6 months in aplastic anemia patients in present study.
Consider interrupting clozapine therapy if the absolute neutrophil count falls below 1,000/[micro]L and clozapine is the suspected cause
8 However the absolute neutrophil count (ANC) is more sensitive and specific indicator of bacterial sepsis than WBC count, particularly if below the normal range has the greatest specificity of neutrophil indices.
In a community based study by Soza et al,11 absolute neutrophil count ( ANC) in whites was 4.
Pancytopenia was defined as hemoglobin (Hb) less than 10g%, absolute neutrophil count (ANC) less than 1.
They were patient age, plasma LD concentration on admission, absolute neutrophil count on admission, and plasma IP-10 concentration during the first week.
Dose-dependent decreases were seen in hemoglobin and absolute neutrophil count (but not platelets), and dose-dependent increases in creatinine occurred.
Patients with advanced central nervous system dysfunction or an initial peripheral absolute neutrophil count below 1,000 cells/[micro]L are not eligible.
After an immediate rise, the absolute neutrophil count will return to normal or below; platelet counts will also fall.
The absolute neutrophil count (ANC) formula is: ANC = (% mature segmental neutrophil [segs] + [bands] nearly mature neutrophils) x WBC.
GlycoPEG-GCSF demonstrated an approximately 30% greater absolute neutrophil count response versus Neulasta.