77% of patients in the combination arm experienced abscopal
tumor shrinkage in un-injected tumors, compared to 54% of patients in the G100+XRT arm.
She said: "Promising pre-clinical data suggests that nanoparticles combined with radiotherapy enhance tumour-specific immune responses and lead to an abscopal
response, priming a patient's immune system to attack cancer cells outside of the radiotherapy target area.
Promising pre-clinical data suggests that nanoparticles combined with radiotherapy enhance tumor-specific immune responses and lead to an abscopal
response, priming a patient's immune system to attack cancer cells outside of the radiotherapy target area," she said.
Knowledge of this abscopal effect goes back for over half a century; radiation oncologists have been well aware that localized radiotherapy can on rare occasion trigger "out-of-target tumor responses" so that tumors elsewhere in the body, areas that were not treated with radiation, shrink.
A 2007 case report of this abscopal effect leading to regression in ovarian cancer, was of particular interest to us as this is the type of cancer our patient has.
These two cases illustrate the abscopal
effect first described in 1953 by Dr.
Optimizing cancer treatments to induce an acute immune response: radiation Abscopal
effects, PAMPs, and DAMPs.
The phenomenon reported by the researchers, known as the abscopal effect, occurs when localized radiation therapy delivered to a single tumor in a patient with advanced disease results in tumor disappearance outside of the irradiated area.
Unexpectedly, other areas where the melanoma had spread (the spleen and the lymph nodes) but that were not directly targeted by the radiation therapy also benefited, consistent with the abscopal effect.
The trial aims to evaluate the ability of NBTXR3 to generate an abscopal
CancerWeb has defined an abscopal effect as "a reaction produced following irradiation but occurring outside the zone of actual radiation absorption.
The abscopal effect is admittedly rare and, in the past, was considered somewhat controversial, since it seemed to fly in the face of common sense.