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Related to abruptio: Placental abruption


 [ab-rup´she-o] (L.)
abruptio placen´tae premature separation of a normally situated but improperly implanted placenta; it usually occurs late in pregnancy, but may take place during labor. Separation of the placenta before the 24th week of pregnancy is considered a spontaneous abortion if the abruption is so severe that the pregnancy is lost.

Contributing factors include multiple pregnancies (grand multiparity), chronic hypertensive disease, direct trauma to the uterus, or sudden release of amniotic fluid.

Premature separation of the placenta is classified from Grade 0 to Grade 3 according to the degree of separation. In Grade 0 mother and fetus are asymptomatic. Diagnosis is made after delivery when the placenta is examined and a clot is found adhering to the maternal surface. Grade 1 is minimal separation that causes some vaginal bleeding and changes in maternal vital signs. Fetal distress and hemorrhagic shock are absent. Grade 2 is moderate separation in which there is evidence of fetal distress and maternal symptoms of a tense uterus and pain on palpation. Grade 3 is the most serious. There is extreme separation which, without prompt intervention, can lead to maternal shock and fetal death.
 Abruptio placentae. A, Mild abruption with concealed hemorrhage. B, Severe abruption with external hemorrhage. C, Complete separation with concealed hemorrhage.
Patient Care. Treatment and patient care are based on the grade of separation and maternal and fetal status. Maternal vital signs are monitored and blood loss is assessed. The uterus is assessed for any tenderness, tension, or rigidity. The location and nature of pain reported by the mother are noted; for example, a sharp stabbing pain high in the fundus can occur when separation begins. Pain that is in addition to the pain of contractions is also significant.

Oxygen may be administered to the mother to limit fetal anoxia. Fetal heart sounds are monitored for signs of fetal distress. The patient is kept in a lateral rather than supine position during labor to prevent pressure on the vena cava and further inhibition of fetal blood supply. Vaginal or pelvic examinations and an enema are restricted lest the placenta be disturbed further.

Grade 2 and Grade 3 separations require delivery as soon as possible, either vaginally or by cesarean section. Without prompt and effective intervention, abruptio placentae can lead to maternal death from hemorrhage, shock, and circulatory collapse. Fetal prognosis depends on the extent of hypoxia suffered by the fetus during labor and delivery.


/ab·rup·tio/ (ab-rup´she-o) [L.] separation.
abruptio placen´tae  premature detachment of the placenta.

abruptio placentae

The premature separation of the placenta from its site of implantation in the endometrium before the delivery of the foetus, commonly known as placental abruption. Some degree of AP occurs in 1:85 deliveries; severe AP with total separation of the placenta is an obstetric emergency seen in 1 in 500–750 deliveries, often accompanied by foetal death.

Clinical findings
Abdominal and/or back pain; irritable, tender or hypertonic uterus; vaginal bleeding (seen in most); 30% are asymptomatic.
Predisposing factors
Pre-eclampsia, eclampsia, chronic hypertension, diabetes, chronic renal disease; mechanical causes are rare (1–5%) and include transabdominal trauma, sudden decompression (as occurs in the delivery of a 1st twin or rupture of membranes in hydramnios) or traction of a short placenta.

Pathophysiology, proposed mechanisms
Local vascular injury of the decidua basalis with bleeding and haematoma formation, which causes shearing of adjacent denuded vessels, exacerbating the bleeding and haematoma; abrupt increased in uterine venous pressure transmitted to intervillous space, resulting in venous bed engorgement and separation of part or the entire placenta.

Expectant therapy if foetus is immature and bleeding limited, treat shock if present; vaginal delivery if possible, or else C-section.

DIC, acute cor pulmonale, renal cortical and tubular necrosis, uterine apoplexy, transfusion hepatitis.

Definable, direct causes that trigger placenta abruptio
Rare (1 to 5%) mechanical factors such as abdominal trauma (for example, from an automobile accident or fall), sudden loss in uterine volume as occurs with rapid loss of amniotic fluid or the delivery of a first twin, or an abnormally short umbilical cord (usually only a problem at the time of delivery). Predisposing factors include the following risk factors: a past medical history of placenta abruptio (after 1 prior episode there is a 10 to 17% recurrence; after 2 prior episodes the incidence of recurrence exceeds 20%); hypertension during pregnancy is associated with up to 18% incidence (however, approximately 50% of placenta abruptio cases severe enough to cause foetal death are associated with hypertension); increased maternal age; increased number of prior deliveries; increased uterine distention (as may occur with multiple pregnancies or abnormally large volume of amniotic fluid); diabetes mellitus in the pregnant woman; cigarette smoking; and drinking alcohol during pregnancy (> 14 drinks per week). The incidence of placenta abruptio, including any amount of placental separation prior to delivery, is about 1 out of 77–89 deliveries; however, the severe form (resulting in foetal death) occurs only in about 1 out of 500–750 deliveries.


Nonphysiologic separation of tissues that should normally adhere.


(a-brup'she-o) [L. abruptio, a breaking away]
A tearing away from.


Three types of placental abruption occur: a. centralis: a partial central detachment with hidden bleeding between the placenta and the uterine wall; occasionally, blood will invade the myometrium (Couvelaire uterus); a. complete: total placental detachment, marked by profuse vaginal bleeding, profound fetal distress, and rapid fetal demise; a. marginalis: partial separation of an edge of the placenta, as evidenced by vaginal bleeding. The large amount of circulating thromboplastin may cause a coagulation defect to occur, resulting in hypofibrinogenemia. See: Couvelaire uterus; disseminated intravascular coagulation

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abruptio placentae

The sudden, premature, partial, or complete detachment of the placenta from a normal uterine site of implantation. The incidence of abruptio placentae is 1:120 births, and the risk of recurrence in later pregnancies is much higher than that for cohorts. Synonym: ablatio placentae See: illustration; placenta


The cause is unknown; however, the condition is most commonly associated with pregnancy-induced hypertension (PIH). It may occasionally be related to abdominal trauma, substance abuse (cigarette, alcohol, or cocaine), or sudden premature rupture of membranes.


Abruptio placentae is classified according to type and severity. Grade 1: vaginal bleeding with possible uterine tenderness and mild tetany; neither mother nor baby is in distress; approximately 10% to 20% of placental surface is detached. Grade 2: uterine tenderness; tetany, with or without uterine bleeding; fetal distress; mother is not in shock. Approximately 20% to 50% of the total surface area of the placenta is detached. Grade 3: Uterine tetany is severe; the mother is in shock, although bleeding may be covert; and the fetus is dead. Often the patient develops coagulopathy. More than 50% of the placental surface is detached.


Extravasation of blood occurs between the placenta and the uterine wall, occasionally between muscle fibers of the uterus. Hemorrhage can be concealed or covert, causing consumptive coagulopathy (disseminated intravascular coagulopathy).


This varies with the type and extent of abruption. Women experiencing only a small marginal separation of the placenta from the uterine wall may be confined to bed and monitored closely for signs of further threat to maternal or fetal status. If prematurity also is a factor, the woman may be given betamethasone to expedite development of fetal pulmonary surfactant. If the woman is at or near term, induction of labor and vaginal delivery may be an option. See: betamethasone

Supportive treatment and prompt surgical intervention are indicated for women who have moderate to severe abruptions. Complete detachment calls for immediate cesarean delivery, concomitant treatment of shock and, sometimes, management of a coagulation defect. The massive loss of blood jeopardizes the mother's survival; fetal mortality is 100%. If the uterus fails to contract after the surgical delivery, immediate hysterectomy may be necessary. See: Couvelaire uterus


Although maternal mortality is unusual, other than as noted, the perinatal mortality is between 20% and 30%.

Patient care

Early recognition and prompt management of the event and any associated complications are vital. The woman's vital signs, fundal height, uterine contractions, labor progress, and fetal status data are monitored, including heart rate and rhythm. Any changes are noted, such as prolonged decelerations in fetal heart rate or alterations in baseline variability; uterine tetany; complaints of sudden, severe abdominal pain; and the advent of or increase in vaginal bleeding. Vaginal blood loss is estimated by weighing perineal pads and subtracting the known weight of dry pads. The interval between pad changes, the character and amount of the bleeding, and the degree of pad saturation are noted. Prescribed IV fluids and medications are administered through a large-bore catheter. A central venous pressure line may be placed to provide access to the venous circulation, and an indwelling catheter is inserted to monitor urinary output and fluid balance. A calm atmosphere is maintained, and the patient's verbalization is encouraged. The patient is assisted in coping with her fears and anxiety. Questions are answered truthfully, comfort measures are implemented, and reassurance is provided as possible and consistent with the current situation and prognosis. All procedures are explained, and the woman and her family are prepared for induction of labor, vaginal delivery, or cesarean birth, as appropriate. The woman must be assured that everything is being done for the neonate's survival, which depends primarily on gestational age, blood loss, and associated hypertensive disorders.


Separation. From Latin abruptus , broken off.
References in periodicals archive ?
These included 4 lesions that were not graded for severity (recent chorionic vessel thrombi, changes consistent with abruptio placenta, diffuse chorioamnionic hemosiderosis, and perivillous fibrin deposition); 4 lesions in which only the most severe variant was more common in cases (meconium-associated vascular necrosis, severe fetal chorioamnionitis, extensive avascular villi, and diffuse chronic villitis); and 1 lesion (increased NRBC) for which both levels of severity were significantly more common in cases, but the odds ratio was higher for the more severe form.
It is not clear by what mechanism exposure to heavy alcohol consumption could cause abruptio placentae.
Risk factors for and perinatal mortality of abruptio placentae in patients hospitalised for early onset severe pre-eclampsia--a case controlled study.
d) Obtained if bleeding, abruptio placentae, or microangiopathic hemolytic anemia.
Primary cause of death that changed as a result of placental histology report N From To 3 Unknown (46) PTL with chorio-amnionitis with intact membranes 14 Chorio-amnionitis 4 Abruptio placentae 1 Treponemal infection 24 IUGR 3 Spontaneous PTL IUGR 2 Chorio-amnionitis IUGR 1 Hypertension-related IUGR 1 Intrapartum hypoxia PTL with chorio-amnionitis with intact membranes 2 Cervical incompetence PTL with chorio-amnionitis with intact membranes 1 Hypertension-related Chorio-amnionitis 2 Maternal disease Chorio-amnionitis Table V.
We emphasize the surprising lack of negative predictive value of a sFlt1 concentration within reference values in pregnancies complicated by abruptio placenta.
Hydramnios, preeclampsia, low-lying placenta, abruptio placentae, multifetal gestations, fetal macrosomia, and shoulder dystocia are all associated with APE, as are both pre- and postterm labor.
Several years ago, for example, we reported on a case of abruptio placentae associated with increases in blood pressure in a pregnant woman whose panic attacks were left untreated.
There are disturbing reports showing that the use of aspirin increases the chance of abruptio placentae, bleeding, and postpartum hemorrhage.
Risk factors for transfusion in the study included anemia, previous C-section, abruptio placentae, chorioamnionitis, placenta previa, abnormal lie (breech or transverse), and previous blood transfusion.
It is associated with obstetric complications such as abruptio placentae, pre-eclampsia/eclampsia, amniotic fluid embolism, retained intrauterine fetal demise, and septic abortion.