aberrant crypt foci

aberrant crypt foci (colon)

A histopathological lesion which is regarded as the intermediate step between normal colonic epithelium and adenomatous growth.

Clinical findings
Patients may present with peptic-ulcer disease-like symptoms, nausea, vomiting, upper-GI bleeding; peak incidence is in middle-aged males (male:female ratio is 2:1).
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Another observation made was rats consuming dried plums had significantly reduced numbers of aberrant crypts, aberrant crypt foci and high-multiplicity aberrant crypt foci compared to control rats.
Based on our laboratory experience, this time (at the dose of AOM used) was associated with the occurrence of a significant number of aberrant crypt foci (ACF), polyps and tumours.
The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice.
4) In the laboratory, scientists fed rats different types of lentils for five weeks before inducing them with the carcinogen azoxymethane, which leads to the formation of lesions known as aberrant crypt foci that precede colon cancer.
Kunihiro Hosono of the Yokohama City University School of Medicine, Japan, and colleagues wrote, "This first reported trial of metformin for inhibiting colorectal carcinogenesis in humans provides preliminary evidence that metformin suppresses colonic epithelial proliferation and rectal aberrant crypt foci, suggesting its promise for the chemoprevention of colorectal cancer" (Cancer Prev.
A comparison of the capacity of different fibres to increase butyrate production confirmed that only fibres promoting stable butyrate production in the colon, such as scFOS, are likely to have an effect on the development of colorectal cancer in rats--by reducing the number of aberrant crypt foci, considered as precancerous lesions of the colonic epithelium.
These experimental studies showed that PEG is the most potent agent against precancerous colonic lesions, or aberrant crypt foci (ACF).
Carrageenan given as a jelly, does not initiate, but promotes the growth of aberrant crypt foci in the rat colon.
The total number of aberrant crypts (AC) and aberrant crypt foci (ACF) were evaluated by means of a dissecting microscope to visualize the ACF and AC.
For example, it is only in the last 5 years that aberrant crypt foci have been identified as an important preinvasive neoplastic lesion in the human colorectal mucosa, even though these lesions were identified several years previously in a rat model of CRC.