abasic


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a·ba·sic

(ă-bā'sik),
1. Affected by, or associated with, abasia.
2. Refers to loss of pyrimidine sites in DNA.
Synonym(s): abatic

a·ba·sic

, abatic (ă-bā'sik, ă-bat'ik)
1. Affected by, or associated with, abasia.
2. Refers to loss of pyrimidine sites in DNA.

abasia

(a-ba'zh(e-)a) [ ¹an- + Gr. basis, step]
1. Motor incoordination in walking.
2. Inability to walk due to impairment of coordination. abasicabatic, adjective

abasia-astasia

Lack of motor coordination with inability to stand or walk. Synonym: astasia-abasia

paralytic abasia

Abasia in which the leg muscles are paralyzed.

paroxysmal trepidant abasia

Abasia caused by trembling and sudden stiffening of the legs on standing, making walking impossible. It may be related to hysteria.
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References in periodicals archive ?
SSB Endo III sites, reflecting either abasic sites or oxopyrimidines, were almost identical in both the exposed and control groups, but in contrast to our previous study (Somorovska et al.
AP endonuclease 1 (Ape1) is the major mammalian abasic endonuclease, accounting for > 95% of the total cellular AP site incision activity (Demple and Harrison 1994).
Using a 26-mer oligonucleotide duplex containing a single, centrally located abasic site analog--the F residue (Figure 1A)--we assessed the effects of several common environmental metals on Ape1 incision capacity.
Ape1 is a functional and structural homolog of ExoIII and belongs to this family of abasic endonucleases.
Briefly, after incubation of Ape1 protein with an inhibitory metal, equimolar or 10-fold excess nonspecific competitor DNA (relative to the labeled F-DNA) was added simultaneously with radiolabeled abasic DNA substrate, and AP site incision was then measured.
Significantly, both Cd(II) and Pb(II) display co-genotoxic effects when combined with methyl methanesulfonate, N-methyl-N-nitrosourea, or N-methyl-N'-nitro-N-nitrosoguanidine, alkylating agents that generate significant levels of BER-type DNA intermediates, including abasic lesions (Fatur et al.
Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleases Nucleic Acids Res 26:2771-2778.
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1.
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in BNA base excision repair: the 3' ends justify the means.