abacavir


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abacavir

 [ah-bak´ah-vir]
a non-nucleoside reverse transcriptase inhibitor used as an antiretroviral in treatment of human immunodeficiency virus infection; administered orally as the sulfate salt.

abacavir

/abac·a·vir/ (ah-bak´ah-vir) a nonnucleoside reverse transcriptase inhibitor used as the sulfate salt as an antiretroviral in the treatment of human immunodeficiency virus infection.

abacavir

(ə-băk′ə-vîr′)
n.
An antiviral drug, C14H18N6O, that is a nucleoside reverse transcriptor inhibitor and is used in its sulfate form in combination with other drugs for the treatment of HIV infection.

abacavir

an antiviral that is a nucleoside reverse transcriptase inhibitor.
indication It is prescribed in combination with other antiretroviral agents for HIV-1 infection.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Hypersensitivity reactions occur in approximately 5% of patients, and can be fatal. Other life-threatening adverse effects include granulocytopenia, anemia, and lactic acidosis. Common side effects include fever, headache, malaise, insomnia, nausea, vomiting, diarrhea, anorexia, and rash.

abacavir

An HIV-nucleoside reverse-transcriptase inhibitor (NRTI/integrase inhibitor) similar to AZT.
 
Adverse effects
Life-threatening allergic reactions—fever, dyspnea, rashes, intraoral blistering, nausea, headache.

abacavir

Ziagen, zintavir, 1592 AIDS An HIV nucleoside reverse transcriptase inhibitor–NRTI/integrase inhibitor similar to AZT Adverse effects Life-threatening allergic reactions–fever, dyspnea, rashes, intraoral blistering, nausea, headache. See AIDS, Nucleoside reverse transcriptase inhibitor, Reverse transcriptase.

abacavir

A nucleoside reverse transcriptase inhibitor drug used in combination with other anti-HIV drugs to treat AIDS. A brand name is Ziagen. In combination with lamivudine and zidovodine it is marketed as Trizivir.
References in periodicals archive ?
Administration of Triumeq is not recommended in patients receiving other products containing abacavir or lamivudine.
17) Two studies of cumulative exposure to NRTIs reached opposite conclusions on whether abacavir or didanosine magnifies MI risk, DAD saying those NRTIs did, (9) the French national team saying they did not.
Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and abacavir in HIV type-1-infected Ugandan children in the ARROW Trial.
High sensitivity of HLA-B*5701 in whites and blacks in immunologically-confirmed cases of abacavir hypersensitivity (ABC HSR).
A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome.
Lamivudine/ abacavir maintains virological superiority over zidovudine/lamivudine and zidovudine/abacavir beyond 5 years in children.
Some investigators have hypothesized that the negative cardiovascular effects of abacavir appear only in patients who are virally suppressed.
Didanosine, abacavir and alcohol use were all associated with a significant risk of developing hepatic stiffness.
Both abacavir and tenofovir DF select for the K65R mutation, which reduces susceptibility to both drugs, as well as to lamivudine [3TC].
Genetic differences among people infected with HIV might help identify the 5 percent of patients who will suffer allergic reactions, ranging from rashes to anaphylactic shock, when given the antiretroviral drug abacavir.