FGF1

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FGF1

A gene on chromosome 5q31 that encodes fibroblast growth factor 1 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF1 interacts with FGF receptors FGFR1, -2, -3 and -4.
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3] Nonstandard abbreviations: PSA, prostate-specific antigen; AR, androgen receptor; AD, androgen dependent; AS, androgen sensitive; AI, androgen independent; KGF, keratinocyte growth factor; EGF, epidermal growth factor; IGF, insulin-like growth factor; IGF-BP, high-affinity IGF-specific binding protein; FGF, fibroblast growth factor; TGF, transforming growth factor; MPR, mouse prostate reconstitution; TbetaR, transforming growth factor-/3 receptor; bFGF, basic fibroblast growth factor; EGFR, epidermal growth factor receptor; FGFR, fibroblast growth factor receptor; aFGF, acidic fibroblast growth factor; and RA, retinoic acid.
Expression (a) and regulation in Growth factor normal prostate TGF-[beta] 1, 2, and 3 Rats/humans: expressed by PE and PM, a2; TGF-bs counterbalance mitogenic effects of other growth factors; expression associated with castration- induced apoptosis (28-32) bFGF Expressed by PE and PS but receptor only in PS, a1; maintains homeostasis (45, 46) aFGF Rats: role in early prostate epithelial development (51) KGF Rats/humans: involved in ductal branching of fetal prostate; paracrine production by PS, receptor (BEK) on PE; [a.
The top contributors to the year-over-year growth include gastrodin injection which increased 443%, cefaclor which increased 224%, and AFGF which increased 193%.