alpha-ketoglutarate dehydrogenase

(redirected from a-ketoglutarate dehydrogenase)

α-ke·to·glu·tar·ate de·hy·dro·gen·ase

an enzyme that catalyzes the oxidative decarboxylation of 2-ketoglutaric acid to succinyldihydrolipoate; the succinyl group is later transferred to CoA and the reduced lipoate is oxidized by NAD+; a complex that is a part of the tricarboxylic acid cycle.