necrosis
[nĕ-kro´sis, ne-kro´sis] (Gr.) the morphological changes indicative of cell death caused by enzymatic degradation.
aseptic necrosis necrosis without infection or inflammation.
Balser's fatty necrosis gangrenous pancreatitis with omental bursitis and disseminated patches of necrosis of fatty tissues.
bridging necrosis septa of confluent necrosis bridging adjacent central veins of hepatic lobules and portal triads characteristic of subacute hepatic necrosis.
central necrosis necrosis affecting the central portion of an affected bone, cell, or lobule of the liver.
coagulation necrosis death of cells, the protoplasm of the cells becoming fixed and opaque by coagulation of the protein elements, the cellular outline persisting for a long time.
fat necrosis necrosis in which fat is broken down into fatty acids and glycerol, usually occurring in subcutaneous tissue as a result of trauma.
liquefactive necrosis necrosis in which the necrotic material becomes softened and liquefied.
massive hepatic necrosis massive, usually fatal, necrosis of the liver, a rare complication of viral hepatitis (fulminant hepatitis) that may also result from exposure to hepatotoxins or from drug hypersensitivity.
moist necrosis necrosis in which the dead tissue is wet and soft.
subcutaneous fat necrosis of newborn a benign, self-limited disease affecting term newborns and young infants, characterized by circumscribed, indurated, nodular areas of fat necrosis. It is thought to be related to trauma on bony prominences during delivery, hypothermia, asphyxia, or maternal diabetes; it usually resolves spontaneously by 2 to 4 weeks with no scarring. Called also
adiponecrosis neonatorum or
subcutanea.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
ne·cro·sis
(nĕ-krō'sis), Pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changes are mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterations are nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, and affected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material.
[G. nekrōsis, death, fr. nekroō, to make dead]
Farlex Partner Medical Dictionary © Farlex 2012
necrosis
(nə-krō′sĭs, nĕ-)n. pl. necro·ses (-sēz′) Death of cells through injury or disease, especially in a localized area of a tissue or organ.
ne·crot′ic (-krŏt′ĭk) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
necrosis
Cell or tissue death due to disease, trauma, hypoxia, radiation, acute infection, etc.; the constellation of changes that accompany and follow irreversible cell injury in living organisms.Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
necrosis
Pathology Cell or tissue death due to disease, trauma, hypoxia, radiation, acute infection, etc; the constellation of changes that accompany and follow irreversible cell injury in living organisms. See Acute tubular necrosis, Aseptic necrosis, Bridging necrosis, Coagulation necrosis, Colliquative necrosis, Contraction band necrosis, Cystic medial necrosis, Fat necrosis, Fibrinoid necrosis, Liquefaction necrosis, Lymph node necrosis, Osteonecrosis, Osteoradionecrosis, Papillary necrosis, Piecemeal necrosis, PORN. McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
ne·cro·sis
, pl. necroses (nĕ-krō'sis, -sēz) Pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changes are mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterations are nuclear pyknosis and abnormally dark basophilic staining; karyolysis, swelling and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, and affected cells may become merged, sometimes forming a focus of coarsely granular, amorphous, or hyaline material.
[G. nekrōsis, death, fr. nekroō, to make dead]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
necrosis
The structural changes, such as those of GANGRENE, that follow death of a body tissue. The most obvious changes are in the cell nuclei which become shrunken and condensed (pyknosis) and no longer take a basic stain. Cell CYTOPLASM becomes more homogeneous and spaces (vacuoles) develop.Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
necrosis
the localized death of plant and animal tissue, such as the response of a leaf to invasion by a pathogen. An affected area is described as being ‘necrotic’. see DIPHTHERIA.Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
Necrosis
The death of cells, a portion of tissue, or a portion of an organ due to permanent damage of some sort, such as a lack of oxygen supply to the tissues.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
necrosis
Death of some or all cells in an organ or tissue. The process involves swelling of the nucleus (pyknosis), fragmentation of the nucleus (karyorrhexis) and complete dissolution of the nuclear chromatin (karyolysis). Necrosis is caused by disease, trauma or interference with blood supply. There are many sequelae to ocular necrosis (e.g. inflammation, reduction in aqueous humour production following ciliary epithelium necrosis, corneal opacity following necrosis of corneal epithelial cells, and visual loss and floaters following retinal necrosis).
See apoptosis;
retinal necrosis.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann
ne·cro·sis
, pl. necroses (nĕ-krō'sis, -sēz) Pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage.
[G. nekrōsis, death, fr. nekroō, to make dead]
Medical Dictionary for the Dental Professions © Farlex 2012
Patient discussion about necrosis
Q. can necrosis in a brain tumor kill you? If so, how? husband has glioblastoma.Tumor seems under control at this point as much as they can tell but sounds like there is a lot of necrosis. He has lots of tumor progression symptoms but since he has had the tumor for so long == 6 years = I guess the necrosis is there moreso than the actual tumor == how dangerous can this be?
A. Tumors and not only in the brain tend to develop necrosis the longer they exist because the tumor cells divide so rapidly so the blood supply can't keep up with its' own cells demands, so some cells within the tumor die (therefore are seen as necrotic). This does not usually predict prognosis, but only means that the tumor is longstanding.
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