high-grade squamous intraepithelial lesion

high-grade squamous intraepithelial lesion (HSIL, HGSIL),

term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion.

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high-grade squamous intraepithelial lesion

Gynecology
A lesion defined by cytologic findings–cells occur singly or in syncytia-like sheets, ↑ nuclear:cytoplasmic ratio, nuclear hyperchromasia that translate into moderate-to-severe dysplasia–CIN 2 to 3/carcinoma in situ of the uterine cervix–a diagnosis made on histology of biopsied tissue, a precancerous lesion. Cf Low-grade squamous intraepithelial lesion.

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

high-grade squa·mous in·tra·ep·i·the·li·al le·sion

(HSIL, HGSIL) (hī-grād skwā'mŭs in'tră-ep-i-thē'lē-ăl lē'zhŭn)

Term used in the Bethesda system for reporting cervical-vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion

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