base substitution

base substitution

The replacement of a single nucleotide in a nucleic acid (e.g., in DNA or RNA) which can be silent—due to “degeneracy” of DNA, in which multiple codons encode the same amino acid—or result in a point mutation with a substituted amino acid or premature termination of transcription or translation.

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base substitution

replacement of a NUCLEOTIDE base in a DNA molecule with another base, possibly producing a SUBSTITUTION MUTATION.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005