acidified serum test

a·cid·i·fied se·rum test

lysis of the patient's red blood cells in acidified fresh serum, specific for paroxysmal nocturnal hemoglobinuria.

Synonym(s): Ham test

Farlex Partner Medical Dictionary © Farlex 2012

A test that assesses susceptibility of erythrocytes to hemolysis, which is markedly increased in paroxysmal nocturnal hemoglobinuria (PNH); see there.
Principle In acidified serum, complement is activated by the alternate pathway, binds to RBCs, and lyses PNH cells which are sensitive to complement activation; positive Ham test also occurs in the rare congenital dyserythropoietic anemia type II, also known as HEMPAS

Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

a·cid·i·fied se·rum test

(ă-sid'i-fīd sēr'ŭm test)

Lysis of the patient's red blood cells in acidified fresh serum, specific for paroxysmal nocturnal hemoglobinuria.
Synonym(s): Ham test.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Ham,

Thomas Hale, U.S. physician, 1905–.

Ham test - lysis of the patient's red cells in acidified fresh serum. Synonym(s): acidified serum test

Medical Eponyms © Farlex 2012