DIO3

An intronless gene on chromosome 14q32 that encodes an iodothyronine deiodinase, which inactivates thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) to its inactive metabolite, 3,3’,5’-triiodothyronine (RT3), and that of the bioactive hormon 3,3’,5-triiodothyronine (T3) to 3,3’-diiodothyronine (T2). DIO3 is highly expressed in the pregnant uterus, placenta, and foetal and neonatal tissues, suggesting a central role in regulating thyroid hormone inactivation during early development.

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