Patient discussion about desmoplasia

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Q. Can cystic fibrosis patients have children?

My boyfriend has cystic fibrosis, and currently he’s treated with many medications but usually healthy (other than pneumonia from hospitalization from time to time). I heard that men with cystic fibrosis can’t have children - is that true? Is there anything he can do about it?
A1WE ARE A HEALTHY COUPLE BUT MY WIFE NEVER GET PREGNANT IN 20 YEARS OF RELATIONSHIP.
I'M SO SORRY ABOUT MY ENGLISH, I'M LEARNING.
A2In addition to the answer above, it’s nowadays possible for cystic fibrosis men to have children with special fertility treatments (try google MESA and ICSI).
A3While 95% of cystic fibrosis men are indeed infertile, it’s nowadays possible for to have children with special fertility treatments.

Q. Do women with cystic fibrosis have difficult pregnancy?

My wife has cystic fibrosis, and after 3 year of marriage we decided we want a baby. I know that men with cystic fibrosis are usually infertile and can’t have children- is that the case also for women with cystic fibrosis? Is the pregnancy in women with cystic fibrosis more problematic? Is it dangerous?
A1Before you attempt a pregnancy, you should consult her doctor to make sure she can tolerate it, because very severe disease can make the pregnancy dangerous for her. If her disease isn’t so severe, usually there are no special problems.
A2If your wife’s disease isn’t severe, and her lungs are functioning fairly well, she can have normal pregnancy. The important thing is to treat the disease intensively to improve the chances of the pregnancy.
A3Women with cystic fibrosis has also problems with fertility, although the chances are much less than in men, only about 20%, and sometimes these problems are reversible and can be treated.

Q. my uncle was diagnosed with pulmonary fibrosis. can anyone help?

A1Pulmonary Fibrosis involves scarring of the lung. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. When the scar forms, the tissue becomes thicker causing an irreversible loss of the tissue’s ability to transfer oxygen into the bloodstream. Traditional theories have postulated that it might be an autoimmune disorder, or the after effects of an infection, viral in nature. There is a growing body of evidence which points to a genetic predisposition. A mutation in the SP-C protein has been found to exist in families with a history of Pulmonary Fibrosis. The most current thinking is that the fibrotic process is a reaction to microscopic injury to the lung. While the exact cause remains unknown, associations have been made with the following:*Inhaled environmental and occupational pollutants, *Cigarette smoking, *Diseases such as Scleroderma, Rheumatoid Arthritis, Lupus,*Therapeutic radiation. For full: http://www.pulmonaryfibrosis.org/ipf.htm Hope this helps.

A2It's a disease in which the lung tissue becomes thickened and more rigid, so the lungs can't function properly. The cause for this is not always known.

Treatment consists of mainly drugs that suppress the immune systems, and have considerable side effects so they are given to patients that are expected to benefit from them- younger (50), mild disease etc.

Lung transplantation is also an effective way of treatment.

You may read more about it here: http://www.nlm.nih.gov/medlineplus/pulmonaryfibrosis.html
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