wild type

a gene, phenotype, or genotype that is so overwhelmingly common among those possible at a locus of interest that it is, in effect, the standard characteristic, and therefore presumably not harmful.

Farlex Partner Medical Dictionary © Farlex 2012

wild type

The typical form of an organism, strain, gene, or characteristic as it occurs in nature, as distinguished from mutant forms.

wild type

Genetics
adjective Referring to an organism or gene locus that predominates in natural or normal populations.

noun The normal condition of a whole organism (wild-type strain) or a particular mutation at a locus or site, which is indicated by a plus sign. The allele of a particular gene that confers the phenotype considered to be the "normal" type commonly found in natural populations. Because some DNA sequence polymorphisms do not produce different phenotypes, there can be multiple "wild-type" alleles of a gene.

Molecular biology
noun The naturally occurring phenotype of an organism; a strain of organism used as a standard reference with which to compare mutant derivatives.

wild type

(wīld tīp)

A gene, phenotype, or genotype that is overwhelmingly common among those possible at a locus of interest, and therefore presumably not harmful.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

wild type

the ‘normal’ PHENOTYPE present in a natural or laboratory population, as distinct from a MUTANT (2) type which often can survive only under artificial conditions. Wild type alleles are usually given a ‘plus’ symbol. Thus the wild type allele of the vestigial wing mutation (vg) in Drosophila is vg+.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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References in periodicals archive

On 1mM NaNO3, growth of the wild type strain inhibited up to 73% at R whilenrtA1 mutant strain exhibited 41% reduction in growth at R of Fosetylaluminium.

EFFECT OF FUNGICIDES ON NITRATE UPTAKE AND ASSIMILATION IN ASPERGILLUSNIDULANS

To assay the effect of high glucose treatment on cultured RPC and investigate whether they respond to high glucose the same as to mesangial cells, RPC were isolated and cultured from wild type and Pa28[alpha][beta]DKO mice.

Proteasome activators, PA28[alpha] and PA28[beta], govern development of microvascular injury in diabetic nephropathy and retinopathy

With the aim of determining whether the mutation affects the dynamic behavior of residues, the RMSF values of wild type and mutant structures were compiled (Figure 3).

Computational analysis reveals the association of threonine 118 methionine mutation in PMP22 resulting in CMT-1A

The wild types and mutants from BHI tubes (Table 1) were grown on blood agar plates.

Global phenotypic characterization of effects of fluoroquinolone resistance selection on the metabolic activities and drug susceptibilities of clostridium perfringens strains

3) divided the mutants and a wild type strain into two main groups distinctly; group A and B.

Genetic Diversity in Hyper Glucose Oxidase Producing Aspergillus niger UAF Mutants by using Molecular Markers

Genotypic Frequencies of wild type gene and pseudogene in Malaria Patients

The association of NCF1 gene with the severity of Malaria

stephensi involved crosses between the mutant and wild type. Progeny derived from each cross was analyzed.

The genetics of green thorax, a new larval colour mutant, non-linked with ruby-eye locus in the malaria mosquito, Anopheles stephensi Liston

"The benefit here was confirmed to the patients with the KRAS wild type tumor," Dr.

KRAS mutation in colon ca blocks Cetuximab

Therefore, the aim of this study is to describe qualitative phenotypic differences between wild type mice, diabetic db/db and diabetic ob/ob mice skulls and teeth.

Of mice and mutations: Phenotypic effects of the diabetic db/db and ob/ob mutations on the skull and teeth of mice

R69 had as many nodules as the wild type with all 18 strains but nodules were tiny, pale white and appeared to be nonfixing.

Registration of ineffective nodulation mutant R69 and nonnodulation mutant R99 common bean genetic stocks

Wild type and mutant Gly [alpha]1 receptors were transiently expressed in HEK 293T cells and subsequently analyzed using the whole cell patch clamp recording technique.

The second transmembrane domain 7' position influences channel kinetics in the glycine [alpha]1 receptor

During acute or chronic infection, many HIV-infected individuals who are not on drug treatment have high levels of circulating virus that is ostensibly wild type; the virus has no detectable mutations that would make it resistant to drugs like tenofovir (Viread) or lopinavir/ritonavir (Kaletra).

Trying to make sense of treatment interruptions