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However, vancomycin CL and volume of distribution were lower compared to other ICU populations due to differences in patients' demographic and clinical parameters.

Determination of vancomycin pharmacokinetics in critically ill intensive care unit patients in Malaysia: A population pharmacokinetic analysis with a nonparametric approach

Ka indicates absorption rate constant; Vz/F, volume of distribution of fentanyl; Clparent2met, clearance of fentanyl by metabolism to norfentanyl; V2, volume of distribution of norfentanyl; Clparent, clearance of fentanyl by all other routes; Clmet, clearance of norfentanyl.

Plasma concentrations of fentanyl achieved with transdermal application in chickens

The fact that clearance (Cl) is a function, whose value depends upon volume of distribution, and that this parameter decreased in renal damaged conditions could be the reason for decreased Cl value of levofloxacin in renal damaged ducks.

Comparative pharmacokinetics of levofloxacin in healthy and renal damaged muscovy ducks following intravenous and oral administration

From the clinical case study (1), the reader might infer that the changes in clearance and the volume of distribution are reduced with time, but previous pharmacokinetic investigations have found no indications for such a finding.

Therapeutic drug monitoring of busulfan

The volume of distribution ([V.sub.d]) is a proportionality constant in pharmacokinetic modeling that relates the total amount of a chemical in the body to the concentration in plasma.

Private drinking water wells as a source of exposure to perfluorooctanoic acid (PFOA) in communities surrounding a fluoropolymer production facility

In horse mean +- SEM area under curve (AUC) was 25.43+-1.07 mg h mL[?] 1, steady state volume of distribution (VDss) was 0.267+-0.014 L.kg-1, half-life (t1/2) was 8.17+-0.602 h, mean residence time (MRT) was 1.4+-0.08 and clearance (Cl) was 0.023+-0.0016 L.h- 1.kg[?] 1 These pharmacokinetic parameters were comparable to the reported values in horse which were VDSS was 0.27+ .06Lkg[?] 1, MRT 9.6+ 3.26 hours and Cl 0.0347+ 0.0033Lh-1kg [?] 1.The respective reported means PK- values in donkeys were AUC 4.6+ 0.880mg h mL[?] 1,

PHARMACOKINETICS OF ECOFRIENDLY MELOXICAM IN HEALTHY HORSES

The volume of distribution at steady state (Vss), which is a sum of volumes of central and tissue compartments, is greater in febrile rabbits than in normal ones.

Comparison of Bioavailability and Pharmacokinetics of Diclofenac Sodium and Diclofenac Potassium in Healthy and Escherichia coli Induced Febrile Rabbits

A 2-g dose of cefepime given intravenously results in peak serum levels of [approximately equal to] 163 [micro]g/mL with a relatively low volume of distribution (0.29 L/kg), which would not be expected to eradicate A.

Optimal therapy for multidrug-resistant acinetobacter baumannii

Each drug is listed with its classification, half life, volume of distribution and normal dosage.

Handbook of forensic toxicology for medical examiners

The fixed-effects parameters were clearance (CL), volume of distribution of the central compartment (V1), central-peripheral clearance (Q2), volume of distribution of the peripheral compartment (V2), central-peritoneal clearance (Q3) and volume of distribution of the peritoneal compartment (V3).

Penetrability of intravenous biapenem into the peritoneal fluid of laparotomy patients and the peritoneal pharmacodynamics against gram-negative bacteria