triple combination therapy

AIDS Any 3-agent antiretroviral regimen—in developing nations, D4T, 3TC and nevirapine—to manage HIV-1 infection; in general, the use of multiple agents of different classes is thought to improve the probability of a positive outcome
Cardiology
(1) The use of 3 agents—e.g., ARBs, beta blockers and ACE inhibitors—to decrease morbidity and mortality in patients with congestive heart failure
(2) Triple antithrombotic therapy The simultaneous use of aspirin, clopidogrel and warfarin. No clots, copious bleeding
Fringe medicine A combination of herbs, yoga, meditation and diet to manage HIV-1+ patients
Gastroenterology A therapy that requires 3 modalities or agents—e.g., TT for H pylori infection includes a proton-pump inhibitor (e.g., omeprazole) and 2 antibiotics (e.g., amoxicillin, clarithromycin)
Hepatology A combination of Zadaxin®, pegylated IFN alpha and ribavirin, used to manage HPV C in nonresponders to IFN and ribavirin alone
Obstetrics The administration of low-dose aspirin, heparin, and prednisone in a habitual aborter with primary antiphospholipid syndrome at an increased risk of DVTs Note: Corticosteroids are ineffective in APS and increase maternal morbidity and foetal prematurity
Oncology—lung The use of 3 different chemotherapeutics—e.g., vinorelbine, gemcitabine, and carboplatin—in patients with non-small cell CA of lung
Oncology—lymphoma Alternating triple therapy The alternating of 3 different chemotherapy regimens—e.g., CHOP-MINE-ESHAP in lymphoma
Oncology—pancreas The use of 3 chemotherapeutics—e.g., gemcitabine, cisplatin, infused fluorouracil—in pancreatic cancer
Pulmonary medicine The use of 3 agents—inhaled corticosteroids, long-acting 2-agonists (e.g., salmeterol) and leukotriene modifiers (e.g., montelukast). Leukotrienes do not help in asthma
Transplantation A 3-agent immunosuppressant regimen—e.g., cyclosporine, azathioprine (or everolimus), and methylprednisolone—to minimize rejection in patients receiving lungs or other transplanted organs See Asthma
Urology The use of hormonal therapy, brachytherapy, and external beam radiation for local control in high-risk prostates See Prostate CA

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triple combination therapy

AIDS See HAART.

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.