S adenosylehomocysteine is the product that is resulted from the AdoMet depenedent
transmethylation reactions.
After
transmethylation reactions, SAM is converted into S-adenosylhomocysteine (SAH) and then hydrolyzed to adenosine and Hcy.
Considered by some authors as an important independent risk factor of atherosclerosis, Hcy can influence the atherosclerosis process in various aspects, through
transmethylation, endothelial injury, inflammation response, and oxidative stress [16].
Christie, "A simple procedure for rapid
transmethylation of glycerolipids and cholesteryl esters," Journal of Lipid Research, vol.
A metabolic disorder of vitamin B12 dependent
transmethylation pathway induced by HIV or cytokine activation is considered the possible cause of vacuolar myelopathy associated with AIDS.
The authors would like to thank Funcap, CNPq and Capes for their financial support and scholarships; to the Chemistry Laboratory of Natural Products and Biotechnology of the Federal University of Ceara, for GC/MS of esters obtained by
transmethylation of fish fatty acids, were analyzed.
The fatty acid composition of the frying oils was determined by gas chromatography (GC) of fatty acid methyl esters (FAME) prepared by
transmethylation with BF3/methanol at 100[degrees]C for 45 min [12].
Hcyis recycled into methionine by a
transmethylation reaction requiring vitamin B12 and folate.
SAM2 encodes an enzyme that catalyzes the formation of S-adenosylmethionine, an important cofactor in cellular
transmethylation reactions.
Homocysteine is a by-product formed in the biologic
transmethylation reactions and detoxified with the methionine synthetase, which is the enzyme depending on vitamin B12, B6, and folate as coenzymes for proper functioning S-adenosylmethionine and methylation.