transcutaneous drug delivery

transcutaneous drug delivery

Transdermal therapy Therapeutics Use of topical prolonged-release forms of drugs; transcutaneous penetration of a drug requires that it traverse the intercellular lipid layer surrounding the cells of the stratum corneum–rather than through the cells themselves, but also the aqueous environment of the basal cells of the epidermis and the dermis Most absorptive sites–in descending order–scrotum, jaw, forehead, scalp, axilla, arm, leg Drugs/agents approved for TDD Clonidine HCl, Estradiol, fentanyl citrate, nicotine, nitroglycerin, scopolamine, testosterone replacement therapy

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.