TABLE 2 Tetanus prophylaxis in wound management (ages 19-64 years) CLEAN MINOR WOUND ALL OTHER WOUNDS * HISTORY OF ADSORBED TDAP OR TD TDAP OR TD TETANUS
TOXOID ([dagger]) TIG ([dagger]) TIG Unknown or <3 Yes No Yes Yes [greater than or equal to]3 No ([double No No ** No dagger]) * Such as, but not limited to, wounds contaminated with dirt, feces, soil, and saliva; puncture wounds; avulsions; and wounds resulting from missiles, crushing, burns, and frosbite.
For each study group, Hiberix was coadministered with recommended routine childhood vaccines (Pediarix [diphtheria and tetanus
toxoids and acellular pertussis (DTaP)/ hepatitis B (HepB)/inactivated poliovirus (IPV)]; Prevnar13 [Pneumococcal 13-valent Conjugate Vaccine], and Rotarix [Rotavirus Vaccine, Live, Oral Suspension]), and noninferiority of immune responses to antigens contained in the coadministered vaccines, with the exception of Rotarix, was assessed.
On March 24, 2015, the Food and Drug Administration licensed an additional combined diphtheria and tetanus
toxoids and acellular pertussis adsorbed (DTaP) and inactivated poliovirus (IPV) vaccine (DTaP-IPV) (Quadracel, Sanofi Pasteur Inc.).
Both vaccines contain diphtheria
toxoid. Here, concerns about increased local reactions are largely theoretical but data are limited, Dr.
therapeutic TIG received 1 5,000 Survived 2 5,000 Died 3 1,000 Died 4 250 Died 5 500 Survived 6 Unknown Survived 7 Unknown Survived 8 3,000 Died 9 5,000 Died Abbreviations: TT = tetanus
toxoid; TIG = tetanus immune globulin; N/A = not applicable.
Arthus reactions and whole limb swelling are hypersensitivity reactions that have been associated with vaccines containing tetanus
toxoid, tetanus and diphtheria
toxoids, and/or pertussis antigens.
However, another study suggested that Td which contains about the same amounts of tetanus and diphtheria
toxoid as does Tdap--can be administered safely 1 month before meningococcal polysaccharide-protein conjugate vaccine, Dr.
In a pivotal clinical study of 4,114 healthy 10-18 year olds, Boostrix (tetanus
toxoid, reduced diphtheria
toxoid, and acellular pertussis vaccine adsorbed [Tdap]) was comparable in both immunogenicity and safety with a currently licensed tetanus-diphtheria toxoid(Td) vaccine and produced antibody responses at least as high as those seen in infants who receive the current higher-antigen DTaP vaccine, said Dr.
That footnote should read, "[paragraph] Tetanus
toxoid, reduced diphtheria
toxoid, and acellular pertussis (Tdap) vaccine on or after age 10 years."