Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study.
An open pilot study of
tiagabine in alcohol dependence: tolerability and clinical effects.
Long-term anxiolytic and antidepressant-like behavioural effects of
tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6mice.
Gabapentin, lamotrigine,
tiagabine, topiramate, oxcarbazepine, levetiracetam, and zonisamide are all recommended for add-on therapy in patients with refractory partial epilepsy (Level A; French et al., 2004a, 2004b).
Currently, disulfiram,
tiagabine, topiramate, and modafinil are the most promising of the available treatments (Karila et al.
The most commonly used drugs are carbamazepine (Calepsin[R]), benzodiazepines (for example, clonazepame [Klonopin[R]]), barbiturates (for example, phenobarbital [Luminal[R]]), primidone (Mysoline[R]), phenytoin (Dilantin[R]), ethosuximide (Zarontin[R]), gabapentin (Neurontin[R]),
tiagabine (Gabitril[R]), topiramate (Topamax[R]), and valproate (Depacon[R]) (Glauser et al., 2006; Ropper & Brown, 2005).
The company currently markets three proprietary products in the United States: PROVIGIL (modafinil) Tablets [C-IV], GABITRIL (
tiagabine hydrochloride) and ACTIQ (oral transmucosal fentanyl citrate) [C-II] , and more than 20 products internationally.
The AEDs produced in the last decade like Gabapetin, Lamotrigine, levetracetam, Oxcarbazepine,
Tiagabine and Topirmate may have fewer effects but no long term follow-ups have yet been done.
Two drugs that potentially will interfere at 335 nm are baclofen (Lioresal[R]) and
tiagabine (Gabatril[R]), both of which coelute with gabapentin.
New antiepileptics approved in the 1990s include felbamate, gabapentin, lamotrigine, topiramate,
tiagabine, and fosphenytoin (Pellock, 1996).
Medications not recommended for treating either sleep initiation or sleep maintenance insomnia include: diphenhydramine, melatonin,
tiagabine, trazodone, tryptophan, and valerian.
Drugs such as gabapentin, lamotrigine, vigabatrin, topiramate,
tiagabine, and zonisamide are the newer ones and currently used as an add-on or alternative therapy.