Since the drug is given as one drop in each eye every waking hour, transfer to the
systemic circulation should be expected, but the amount, if it occurs, has not been reported.
The thought process was that if the patient had PFO or a septal defect, there would be a venue through which an adult worm in the right ventricle could be embolized and enter both the pulmonary circulation and the
systemic circulation to end up in the spleen.
(1) D-transposition (d-TGA) is a cyanotic lesion characterized by inappropriate ventriculoarterial connections leading to parallel pulmonary and
systemic circulations that is best surgically corrected very early in life.
In summary, skin absorption, if assessed as required based on the physical-chemical properties of the compound of interest, should be conducted as part of safety tier to establish an understanding on the potential of a compound applied to skin to penetrate beyond the barrier into the
systemic circulation and internal organs.
It is thought that the marked disruption in the inner ear membranes that takes place during acoustic neuroma surgery acts to release tissue antigens into the
systemic circulation. These antigens then stimulate the immunologic response.
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Systemic circulation conveys blood from the heart to other tissues of the body and from other tissues of the body to heart.
William Harvey, an English physician in the 1600s who is considered the first to describe in detail the
systemic circulation and properties of blood being pumped to the brain and body by the heart.
It contains a reformulation of the drug dihydroergotamine mesylate (DHE) in a proprietary Tempo inhaler that allows DHE to be rapidly absorbed from the pleural mucosa into the
systemic circulation. DHE has been used to treat migraine attacks for decades, administered by intravenous infusion or nasal sprays.
These results indicate that EMPB also enhanced the homing of MSCs from
systemic circulation to the wound site.
Endothelial cells serve as mediators between
systemic circulation and particular organs, and the cytoskeleton in turn is crucial to regulation of internal function in any cell.
Particulate matter (PM) has been consistently associated with cardiovascular disease development and progression, (1,2) and is believed to contribute to development either indirectly through the autonomic nervous system or inflammatory responses, or directly via entry into
systemic circulation and subsequent damage to blood vessels.