The enzymes hydroxymethylglutaryl-CoA reductase, type III geranylgeranyl diphosphate
synthase, phosphomevalonate kinase, hydroxymethylglutaryl-CoA
synthase, prenylcysteine oxidase/farnesylcysteine lyase, and protein farnesyltransferase subunit beta are each coded by two copies of the genes.
When the barrier function of the endothelium is violated, systemic and local inflammatory mediators are produced under the influence of risk factors (smoking, hypercholesterolemia, hyperinsulinemia, arterial hypertension, menopause, etc.), leading to a decrease in the stability of endothelial NO
synthase that is leading to the development of endothelial dysfunction [12].
Conclusion: The association between depressed endothelial nitric oxide
synthase activation and insufficient endothelin-1 synthesis in the early days of life of very-low-birth-weight infants might be one of the causes of more serious and irreversible injury of brain tissue.
(1994) Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide
synthase 2.
To the best of our knowledge, this is the first reported case of a Saudi infant with aldosterone
synthase deficiency due to a homozygous alteration (c.1398+2T>A) in CYP11B2 that has not been described in the literature or any databases thus far.
cereus tsul should express class IV PHA
synthase, which is composed of subunits PhaC and PhaR.
Molecular cloning of the mammalian fatty acid
synthase gene and identification of the promoter region.
In infancy, aldosterone
synthase deficiency generally takes the form of a life-threatening electrolyte imbalance.
Target: Rights to the leukotriene C4
synthase inhibitor programme (OX-CLI project)