sulfonylurea

[sul″fo-nil-u´re-ah]

any of a class of compounds that exert hypoglycemic activity by stimulating the islet tissue to secrete insulin; used to control hyperglycemia in patients with type 2 diabetes mellitus who cannot be treated solely by diet and exercise. The class includes the oral hypoglycemic agentsacetohexamide, chlorpropamide, glipizide, tolazamide, and tolbutamide.

sulfonylurea

(sŭl′fə-nĭl-yo͝o-rē′ə)

Any of a group of hypoglycemic drugs, such as glyburide, that act on the beta cells of the pancreas to increase the secretion of insulin and are used in the treatment of type 2 diabetes.

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References in periodicals archive

Those taking Sulphonylureas once daily should take it with Iftar.

People with diabetes will listen more to Religious scholars rather than doctors, hence we need to educate them-Dr. Hassanein

In the Canagliflozin in Ramadan Tolerance Observational Study (CRATOS), fewer people receiving canagliflozin (n=162) experienced hypoglycaemia compared to those receiving sulphonylurea (n=159) (adjusted odds ratio: 0.273 [95% CI: 0.104, 0.719]).

Expert Opinion: Use of sodium glucose co-transporter type-2 inhibitors in South Asian population-The Pakistan perspective

We describe the first homozygous ABCC8 mutation with hyperinsulinemic hypoglycaemia (HH) in the neonatal period and its evolution to complete insulin deficient, sulphonylurea responsive diabetes mellitus.

Congenital Hyperinsulinism and Evolution to Sulfonylurea-responsive Diabetes Later in Life due to a Novel Homozygous p.L171F ABCC8 Mutation

Switching from sulphonylurea to a sodium-glucose cotransporter2 inhibitor in the fasting month of Ramadan is associated with a reduction in hypoglycaemia.

Safety of Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2-I) During the Month of Ramadan in Muslim Patients with Type 2 Diabetes

Nazim et al., "The identification of a R201H mutation in KCNJ11, which encodes Kir6.2, and successful transfer to sustained-release sulphonylurea therapy in a subject with neonatal diabetes: evidence for heterogeneity of beta cell function among carriers of the R201H mutation," Diabetologia, vol.

Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity

Of these 70% had hypoglycaemia with sulphonylureas.

Clinical study of diabetes in elderly

Empagliflozin as add-on to metformin plus sulphonylurea in patients with type 2 diabetes.

Overview of the efficacy and safety of SGLT-2 inhibitors in type 2 diabetes mellitus

Rifampicin, which is key among the cocktail of anti-TB drugs, through enzyme induction, accelerates the metabolism of sulphonylureas and biguanides, reducing their plasma levels and thereby leading to hyperglycemia [3, 41].

The Bidirectional Relationship between Tuberculosis and Diabetes

Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metfomin in patients with newly diagnosed non-insulin dependent diabetes followed for three years.

COMPARISON BETWEEN METFORMIN AND INSULIN IN TREATMENT OF GESTATIONAL DIABETES MELLITUS AND EFFECT ON NEONATAL HYPOGLYCAEMIA

Among sulphonylurea, Glimepiride was more prescribed (23.5%), than Glibenclamide (17.5%) and Gliclazide (4%).

Prescription Pattern of Antidiabetic Drugs among Type 2 Diabetes Patients of Sir Ganga Ram Hospital, Lahore

"Patients treated with metformin had a small but statistically signiY=cant improvement in survival compared with the non-diabetics, whereas those treated with sulphonylureas had a consistently reduced survival compared with nondiabetic patients.

Diabetes drug could help us live longer

Complexation of sulphonylurea with lighter transition metals has been studied in detail by Yoshinaga and Yamamotto [5, 6] and complexation of sulphonylurea and biguanidine by Iqbal et al.

Synthesis, spectral characterization, magnetic moment, mass, X-ray diffraction, and kinetic (TGA) studies of Cr(III) complex with metformin: an oral antidiabetic drug