Four novel p.N385K, p.V36A, c.1033-1034insT and c.1417-1418delCT mutations in the
sphingomyelin Phosphodiesterase 1 (SMPD1) gene in patients with types A and B Niemann-Pick disease (NPD).
Koo, "Milk
sphingomyelin is more effective than egg
sphingomyelin in inhibiting intestinal absorption of cholesterol and fat in rats," Journal of Nutrition, vol.
Two major pathways,
sphingomyelin hydrolysis and de novo biosynthesis, have been implicated in the generation of ceramide.
Jiang et al., "Association of plasma
sphingomyelin levels and incident coronary heart disease events in an adult population multi-ethnic study of atherosclerosis," Arteriosclerosis Thrombosis and Vascular Biology, vol.
Sphingomyelin is the most abundant of the 7 types of sphingolipids, constituting approximately 5-6 mol % of total lipids.
The mammalian T-tubule membranes are highly enriched in
sphingomyelin and cholesterol compared to the surface sarcolemma [9].
According to the authors, this increase in red cell rigidity might be due to enhanced
sphingomyelin values [30].
By means of UPLC/MS technology, we found in a previous study that there are significant changes between the phospholipid levels of AMI patients before I/R treatment compared to healthy controls – specifically, glycerophospholipid is significantly down-regulated and most
sphingomyelin are up-regulated.[sup][7] We found similar changes in phospholipid metabolic pathways after emergency reperfusion therapy in the infarction zone of youth STEMI patients, in accordance with our previously published results; moreover, as discussed above, sphingolipid metabolism was the top most altered metabolic factor.
Along with an increase in maintenance of total phospholipids (TP) (P < 0.01), fractions of lysophosphatidylcholine (LPC), phosphatidylserine (PS), phosphatidylethanolamine (PEA) (P < 0.05) raise and the maintenance of fractions
sphingomyelin (SPM) (P < 0.01), phosphatidylcholine (PC) (P < 0.01) decreases that lead to an increase in a value of the coefficient saying of a relation between easily oxidizable (PS, PEA) to difficult oxidizable (SPM, PC).
Phosphatidilcholine and
sphingomyelin profiles vary in Bos taurus x indicus and Bos taurus x taurus in vitro and in vivo-produced blastocysts.