Medical

single-chain antibody

single-chain antibody

A synthetic antibody based on a single-chain fragment, which is a fusion protein of the variable regions of the heavy and light chains of immunoglobulins, connected with a short linker peptide of 10–25 amino acids. Single chains are one of the smallest possible formats for recombinant antibodies, and have potential roles as diagnostic tools and therapeutic agents.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
According to the company, Brolucizumab (RTH258) is a humanized single-chain antibody fragment (scFv) to reach this stage of development.
Novartis submits brolucizumab (RTH258) NDA with the US FDA under priority review for treating patients with wet AMD
Dubel, "A helper phage to improve single-chain antibody presentation in phage display," Nature Biotechnology, vol.
Generation of Recombinant Antibodies against the beta-(1,6)-Branched beta-(1,3)-D-Glucan Schizophyllan from Immunized Mice via Phage Display
COPENHAGEN -- An ultrasmall yet highly potent single-chain antibody fragment directed against tumor necrosis factor-alpha showed promise for the treatment of Behcet's disease flares in a pilot phase II study.
DLX105 is a novel treatment strategy for Behcet's
Bypassing hybridoma technology: HLA-C reactive human single-chain antibody fragments (scFv) derived from a synthetic phage display library (HuCAL) and their potential to discriminate HLA class 1 specificities.
Optimization of gene transfection in murine myeloma cell lines using different transfection reagents
ESBA105 is a single-chain antibody fragment directed against TNF?.
ESBATECH'S ANTIBODY FRAGMENT ENTERS CLINICAL DEVELOPMENT
Use of an in vivo biotinylated single-chain antibody as capture reagent in an immunometric assay to decrease the incidence of interference from heterophilic antibodies.
Automated time-resolved immunofluorometric assay for progastrin-releasing peptide
This mechanism of action has been validated by experiments with single-chain antibody fragments containing the antibody binding site (15).
Passive antibody administration (immediate immunity) as a specific defense against biological weapons. (Perspective)
and Inhale announced a broad strategic alliance that includes a collaboration to develop three products using Inhale's Inhance(TM) pulmonary delivery platform or SEDS(TM) supercritical fluids platform; an agreement making Inhale solely responsible for licensing Enzon's PEG patents, which includes over 40 US patents; an option for Enzon to license Inhale's PEGylation patents; and an agreement to explore the development of non-invasive delivery of single-chain antibody products via the pulmonary route.
INHALE REPORTS INCREASE IN REVENUES FOR 4TH QTR/YEAR END
According to researcher Robert Bird of the Gaithersburg, Md.-based company, recent tests show this "single-chain antibody" binds specifically to its antigen.
Half an antibody: better than one?
According to the company, LME 636 is based on a proprietary single-chain antibody fragment technology specifically designed for topical delivery.
Oculis acquires the license to the novel phase II-stage Anti-TNF alpha antibody fragment
During the last decade combinatorial technologies have enabled the selection of a variety of monoclonal single-chain antibody fragments (scFv) against all types of antigens and epitopes (8-10).
Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries
Copyright © 2003-2025 Farlex, Inc Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.