reconstructed ion chromatogram

A normal mass spectrometric data set consisting of full mass spectra recorded sequentially in time as a sample is passed to the ion source, either from a direct-insertion probe or from a chromatograph (e.g., GC/MS). The total ion current trace is the sum of ion abundances in each mass spectrum plotted vs time.

Each spectrum contains a pattern of molecular ions and fragment ions, which can be specified, and data plotted of scan-by-scan abundance of specific ions vs time—the so-called reconstructed ion chromatogram (RIC). The RIC can be used to identify all ions belonging in a single mass spectrum, based on their coincident peaks in time, while discriminating against background ions, and can be used to screen a GC/MS run for related classes of compounds by re-constructing ion chromatograms for common structurally specific ions.

References in periodicals archive

Abstract: Mass spectra of reconstructed ion chromatogram (MRIC) technique are used to follow up the grafting copolymerization of 1-vinyl-2-pyrrolidinone (VP) 1-vinyl-3-anisylidine-2-pyrrolidinone (VAP) and ethylmethacrylate (EMA) and cellulose extracted from kenaf using xanthate method.

Grafting of Cellulose Extracted from Kenaf Using Xanthate Method

3, B, D, and F, shows reconstructed ion chromatograms (RICs) appropriate to monohydroxycholesterols and hydroxycholest-4-en-3-ones (HC/HCO, m/z 539.437/ 534.405), 30-HCA/3O-CA (m/z 553.416/548.385), and 3[beta], 7[alpha]-diHCA/7[alpha]H, 3O-CA (m/z 569.411/ 564.380) from O7AHD (upper panels) and control plasma (lower panels) samples derivatized with [[sup.2][H.sub.5]]GP (ii) and [[sup.0][H.sub.5]]GP (i), respectively.

Quantitative charge-tags for sterol and oxysterol analysis

For the quantification of sterols, we recorded only [MS.sup.2] spectra and generated reconstructed ion chromatograms (RICs) for the [[M].sup.+][right arrow] [[M-79].sup.+] transitions over the duration of the LC-[MS.sup.2] run.

Potential of sterol analysis by liquid chromatography-tandem mass spectrometry for the prenatal diagnosis of Smith-Lemli-Opitz syndrome

Reconstructed ion chromatograms of a blank plasma enriched with IS and therapeutic concentrations of all 8 sulfonylureas are shown in Fig.

Identification and quantification of 8 sulfonylureas with clinical toxicology interest by liquid chromatography-ion-trap tandem mass spectrometry and library searching

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