pros·tat·ic in·tra·ep·i·the·li·al ne·o·pla·si·a (PIN),

dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with cell crowding, variation in nuclear size and shape, and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with cell crowding, nucleomegaly and nucleolomegaly, and irregular cell spacing.

Farlex Partner Medical Dictionary © Farlex 2012

pros·tat·ic in·tra·ep·i·the·li·al ne·o·pla·si·a

(PIN) (pros-tat'ik in-tra-ep'i-thē'lē-ăl nē'ō-plā'zē-ă)

Dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with variation in nuclear size and shape and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with nucleomegaly, nucleolomegaly, and irregular cell spacing.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive

Do not misinterpret intraductal carcinoma of the prostate as high-grade prostatic intraepithelial neoplasia! Eur Urol.

Essential Updates in Grading, Morphotyping, Reporting, and Staging of Prostate Carcinoma for General Surgical Pathologists

The core is extensively involved by foamy gland high-grade prostatic intraepithelial neoplasia (HG PIN).

Case--Foamy high-grade prostatic intraepithelial neoplasia: A false positive for prostate cancer on mpMRI?

As prostatic intraepithelial neoplasia is a precursor lesion for prostatic carcinoma, it needs to be detected as early as possible.

PATTERNS OF PROSTATIC INTRAEPITHELIAL NEOPLASIA

Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol.

Use of Non-steroidal Anti-inflammatory Drugs for Chemoprevention of Inflammation-induced Prostate Cancer/Inflamasyonla Tetiklenen Prostat Kanserlesmesinin Onleyici Tedavisinde Non-streoidal Anti-inflamatuvar IlaC Kullanimi

High-grade prostatic intraepithelial neoplasia: the most likely precursor of prostate cancer.

Matrix metalloproteinases 2 and 9 expression in canine normal prostate and with proliferative disorders/Expressao de metaloproteinases de matriz 2 e 9 na prostata canina normal e com lesoes proliferativas

The significance of a typical adenomatous hyperplasia and prostatic intraepithelial neoplasia for the development of prostate carcinoma.

FREQUENCY OF PROSTATE CANCER IN PATIENTS UNDERGOING TRANS-URETHRAL RESECTION OF PROSTATE (TURP) FOR CLINICALLY BENIGN SYMPTOMATIC ENLARGED PROSTATE

Patients with more than one prior negative prostate biopsy, a previous diagnosis of prostate cancer, or evidence of high-grade prostatic intraepithelial neoplasia (HGPIN) or atypical small acinar proliferation (ASAP) on the pre-entry biopsy were excluded.

Dutasteride shown to lower risk of prostate cancer: agent lowered risk by 23.5% at 4 years

Prostatic intraepithelial neoplasia. Adv Anat Pathol 1:123-34.

Cell proliferation and volume-weighted mean nuclear volume in high-grade PIN and adenocarcinoma, compared with normal prostate

GTx is developing ACAPODENE(R) (toremifene citrate), a selective estrogen receptor modulator, or SERM, in two separate clinical programs in men: first, a pivotal Phase III clinical trial for the treatment of serious side effects of ADT for advanced prostate cancer, and second, a pivotal Phase III clinical trial for the prevention of prostate cancer in high risk men with high grade prostatic intraepithelial neoplasia, or PIN.

ACAPODENE LOWERED CHOLESTEROL AND RAISED HDL IN PHASE III

Investigator David Price, M.D., reported a 48% reduction in prostate cancer risk for high-grade prostatic intraepithelial neoplasia (PIN) patients who took 20 mg of toremifene each day for a full year.

Drug may prevent prostate Ca in high-risk patients: prostatic intraepithelial neoplasia patients who took toremifene had a 48% drop in prostate cancer risk

Human glandular kallikrein 2 (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker.

Standardization as a private enterprise

Conversely, common premalignant and malignant cribriform lesions include high-grade prostatic intraepithelial neoplasia (HGPIN) and the cribriform pattern of invasive acinar adenocarcinoma (Gleason pattern 4), respectively, and less common entities, though still clinically important, are ductal adenocarcinoma and intraductal carcinoma of the prostate (IDC-P).

Spectrum of Cribriform Proliferations of the Prostate: From Benign to Malignant