prolactinoma

[pro-lak″tĭ-no´mah]

a pituitary adenoma made up of lactotrophs that secretes excessive amounts of prolactin; this may delay puberty in either sex, cause galactorrhea-amenorrhea syndrome in women, or decrease libido and fertility in men. Called also prolactin cell or prolactin-secreting adenoma and lactotrope or lactotroph adenoma.

pro·lac·tin-·pro·duc·ing ad·e·no·ma

a pituitary adenoma composed of prolactin-producing cells; it gives rise to symptoms of nonpuerperal amenorrhea and galactorrhea (Forbes-Albright syndrome) in women and to impotence in men.

Synonym(s): prolactinoma

Farlex Partner Medical Dictionary © Farlex 2012

prolactinoma

Endocrinology A pituitary tumor more common in Pts < age 40 characterized by an excess secretion of prolactin–tumor size correlates with the prolactin level; smaller tumors, microprolactinomas, are more common in ♀; macroprolactinomas are more common in ♂ and associated with sexual dysfunction; women may become symptomatic while on OCs; menses may stop when OCs are discontinued; prolactinomas may grow during pregnancy and be diagnosed postdelivery. See Prolactin.

pro·lac·tin-pro·duc·ing ad·e·no·ma

(prō-lak'tin-prŏ-dūs'ing ad'ĕ-nō'mă)

A pituitary adenoma composed of prolactin-producing cells; it gives rise to symptoms of nonpuerperal amenorrhea and galactorrhea (Forbes-Albright syndrome) in women and to impotence in men.
Synonym(s): prolactinoma.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

prolactinoma

A benign tumour of the PITUITARY GLAND that secretes large quantities of the hormone PROLACTIN. The tumour can cause blindness by pressing on the OPTIC CHIASMA and may be suspected because of unexpected milk production (lactation). Treatment is by surgery or by drugs.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

Overall majority of pituitary lesions are pituitary prolactinoma. Sparse documentation is available to reflect the estimates of the prevalence of pituitary diseases from Pakistan.

Pattern of Pituitary Lesions at the Endocrine Center of a Tertiary Care Hospital

Characteristics of pericytes in diethylstilbestrol (DES)-induced pituitary prolactinoma in rats.

Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy/Perdida y Desprendimiento de Pericitos en la Neuropatia Experimental Inducida por Cisplatino

When the cases with a prolactinoma (n=139) were divided into two groups, micro- and macroadenoma, there were no statistically significant differences in terms of age.

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Inhibition of SKP2 sensitizes bromocriptine-induced apoptosis in human prolactinoma cells.

Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis

First line therapy for all the pituitary adenoma is surgical resection except for prolactinoma which has excellent response to pharmacological therapy.1 Endoscopic transsphenoidal surgery was developed under a minimally invasive surgical strategy.

Endoscopic Trans-Sphenoidal surgery: Efficacy and response in pituitary adenoma

(1,5) A prolactin level >250 ng/mL is usually indicative of a prolactinoma; however, some medications, such as strong D2 receptor antagonists (eg, risperidone, haloperidol), can cause significant elevation without evidence of prolactinoma.

Strategies for managing medication-induced hyperprolactinemia

GEO ID Normal : case Contributor Year 0:10 GSE4237 8 resected human pituitary tumor (1 Hussaini IM 2006 recurrent + 1 nonrecurrent + 1 invasive + 1 noninvasive + 4 undefined) +2 HP75 tumor cell line 0:13 GSE22812 Prolactin pituitary tumors (5 Wierinckx A 2011 noninvasive + 2 invasive + 6 aggressive-invasive) 0:16 GSE46311 16 somatotroph adenoma (also known as Lekva T 2013 growth hormone-producing somatotroph pituitary adenomas) 3:4 GSE36314 4 human prolactinoma Oyesiku NM 2012 3 human normal pituitary 3:7 GSE51618 3 pituitary glands Feng J 2013 7 NFPAs (nonfunctioning pituitary adenomas) (4 noninvasive NFPAs + 3 invasive NFPAs)

Corrigendum to "Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data"

Ollero Garcia-Agullo, "Grupo de Trabajo de Neuroendocrinologia de la S [Clinical guidelines for diagnosis and treatment of prolactinoma and hyperprolactinemia]," Endocrinologia y Nutricion, vol.

Change in Prolactin Levels in Pediatric Patients Given Antipsychotics for Schizophrenia and Schizophrenia Spectrum Disorders: A Network Meta-Analysis

Giant prolactinoma is defined as a pituitary tumour with a largest diameter of 40 mm or more in any direction with massive extrasellar extension and very high prolactin levels (usually above 1000 [micro]g/L) and no concomitant GH or ACTH secretion [1-4].

Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome