primosome

pri·mo·some

(prī'mō-sōm),

A complex of proteins that bind with primase at specific sequences of DNA that serve as the sites for the formation of RNA primers; a part of the replisome.

[primer + -some]

Farlex Partner Medical Dictionary © Farlex 2012

primosome

a complex of proteins, including the enzymes HELICASE and PRIMASE, involved in replication of some genomes, such as the CHROMOSOME of ESCHERICHIA COLI and of the BACTERIOPHAGE (|)X174.

The primosome moves along the single-stranded DNA, on the lagging strand, promoting the formation of RNA PRIMERS at the replicating fork (see DNA (b) REPLICATION).

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005