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prekallikrein

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prekallikrein

 [pre-kal″ĭ-kre´in]
a plasma protein that is the proenzyme of plasma kallikrein; it is cleaved to its active enzyme form by activated coagulation factor XII.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pre·kal·li·kre·in

(prē'kal-ĭ-krē'in),
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII. Prekallikrein also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor
Farlex Partner Medical Dictionary © Farlex 2012

pre·kal·li·kre·in

(prē'kal-i-krē'in)
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII; also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Fletcher,

surname of the patient in whom the defect was first noted.
Fletcher defect - slow contact activation in coagulation of the blood.
Fletcher factor - factor found in coagulation studies, revealing a slow contact activation but not associated with bleeding abnormalities. Synonym(s): prekallikrein
Medical Eponyms © Farlex 2012

pre·kal·li·kre·in

(prē'kal-i-krē'in)
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII; also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor.
Medical Dictionary for the Dental Professions © Farlex 2012
Mentioned in
References in periodicals archive
However, for any given DIC stimulus, more than one activation pathway may be involved (see Table 4).[6,7] When endothelial cells are damaged, the exposed collagen activates FXII, which stimulates the intrinsic pathway and converts prekallikrein to kallikrein to activate fibrinolysis.
A review of disseminated intravascular coagulation: presentation, laboratory diagnosis and treatment
Basically, aPTT is affected by the activities of clotting factors XII, XI, X, IX, VIII, V, II, and I, as well as by high molecular weight kininogen and prekallikrein. Measuring the PT and the thrombin time (TT) can efficiently narrow the number of required analyses.
A 77-year-old man with a prolonged activated partial thromboplastin time
Activated factor XII converts prekallikrein into kallikrein, and the latter cleaves high-molecular-weight kininogen into bradykinin, which mediates many of the biologic effects of this system.
A girl with severe hand swelling and abdominal cramps
An isolated result showing aPTT prolongation suggests a deficiency or inhibitor of one or more of the intrinsic pathway clotting factors (prekallikrein, high molecular weight kininogen, factors XII, XI, IX, and VIII).
Evaluation of a prolonged prothrombin time
Fibrinogen Vitamin K-dependent Contact Fibrinogen Factor II Factor XII Factor V Factor VII HMWKa Factor VIII Factor IX Prekallikrein (b) Factor XIII Factor X Factor XI (a) HMWK, high-molecular weight kininogen, also known as Fitzgerald factor.
Coagulation and bleeding disorders: review and update
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