platelet neutralization procedure

platelet neutralization procedure (PNP),

a technique based on the ability of platelets to bypass the effect of a lupus anticoagulant by correcting prolonged coagulation times in various phospholipid-dependent test systems; the disrupted platelet membranes in the freeze-thawed platelet suspension neutralize phospholipid antibodies in the plasma of patients with lupus anticoagulant; after the patient plasma is mixed with the freeze-thawed platelet suspension, the activated partial thromboplastin time will be corrected when compared with the original baseline activated partial thromboplastin time.

Farlex Partner Medical Dictionary © Farlex 2012

plate·let neut·ral·i·za·tion pro·ce·dure

(PNP) (plāt'lĕt nū'trăl-ī-zā'shŭn prŏ-sē'jŭr)

A technique based on the ability of platelets to bypass the effect of a lupus anticoagulant by correcting prolonged coagulation times in various phospholipid-dependent test systems; the disrupted platelet membranes in the freeze-thawed platelet suspension neutralize phospholipid antibodies in the plasma of patients with lupus anticoagulant; after the patient's plasma is mixed with the freeze-thawed platelet suspension, the activated partial thromboplastin time will be corrected when compared with the original baseline activated partial thromboplastin time.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012