penicillamine

[pen″ĭ-sil´ah-mēn]

a degradation product of penicillin that chelates certain heavy metals; used orally to reduce the blood copper level in Wilson's disease and to promote excretion of cystine in patients with cystinuria or recurrent cystine renal calculus formation, by helping to solubilize cystine. It is also used as a disease-modifying antirheumatic drug in treatment of refractory rheumatoid arthritis.

pen·i·cil·la·mine

(pen'i-sil'ă-mēn),

A degradation product of penicillin; a chelating agent used in the treatment of lead poisoning, hepatolenticular degeneration, and cystinuria, and in the removal of excess copper in Wilson disease.

Synonym(s): β, β-dimethylcysteine

Farlex Partner Medical Dictionary © Farlex 2012

penicillamine

(pĕn′ĭ-sĭl′ə-mēn′)

A chelating agent, C₅H₁₁NO₂S, that is a degradation product of penicillin and is used in the treatment of Wilson disease, refractory rheumatoid arthritis, and excess urinary excretion of cystine.

penicillamine

Metabolic disease A drug that removes copper, lead, mercury, and other metals from the body, which inhibit angiogenesis in brain tumors

pen·i·cil·la·mine

(pen'i-sil'ă-mēn)

A degradation product of penicillin; a chelating agent used to treat lead poisoning, hepatolenticular degeneration, and cystinuria.
Synonym(s): β, β-dimethylcysteine.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

penicillamine

A drug used to treat severe RHEUMATOID ARTHRITIS not responding to nonsteroidal anti-inflammatory drugs (NSAIDs).

Penicillamine is a CHELATING AGENT and is also used to treat poisoning with metallic salts or disorders such as WILSON'S DISEASE. The drug is on the WHO official list. Brand names are Distamine and Pendramine.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Penicillamine (Cuprimine, Depen)

A drug used to treat medical problems (such as excess copper in the body and rheumatoid arthritis) and to prevent kidney stones. It is also sometimes prescribed to remove excess lead from the body.

Mentioned in: Lead Poisoning

pen·i·cil·la·mine

(pen'i-sil'ă-mēn)

Degradation product of penicillin used to treat lead poisoning, hepatolenticular degeneration, and cystinuria.

Medical Dictionary for the Dental Professions © Farlex 2012

Mentioned in

References in periodicals archive

Penicillamine has been used in mercury poisoning (one report), in addition to its indication as a chelating agent for copper in the treatment of Wilson's disease.

Drugs, pregnancy, and lactation: antidotes, detoxification agents

Elemental analysis, Mossbauer, and EPR spectroscopy confirmed that the structure is similar to that of complex (I), but instead of the penicillamine thiol ligands two molecules GSH are present [21].

Reversible dissociation and ligand-glutathione exchange reaction in binuclear cationic tetranitrosyl iron complex with penicillamine

In this case, the measurement of seral or urine copper, in the rats, is not necessary, because the penicillamine chelates the free copper and so the monitoring test will be not valid [25].

The protective effect of Penicillamine against Bleomycine induced pulmonary fibrosis in rats

N-acetyl cysteine (NAC) and penicillamine (PEN) have been shown to induce apoptosis in multiple types of human cancer cells; however, the molecular mechanism underlying this activity is unclear.

N-acetyl cysteine

Low-dose methotrexate (5 to 15 mg once weekly) is now being used more often, before therapy with gold salts or penicillamine, with improvement in symptoms, although the mechanism of action is debatable.

Arthritis--rheumatoid and osteo: ONF-07-13-I

This process of endothelial activation by copper can be reversed using chelating agents like penicillamine (59), a property that is widely exploited in designing therapeutic regimens (see section below).

Copper & biological health

Five had been treated with chelation therapy (penicillamine and/or zinc) for >3 years.

Diagnostic accuracy of serum ceruloplasmin in Wilson disease: determination of sensitivity and specificity by ROC curve analysis among ATP7B-genotyped subjects

2) Penicillamine (D-Pen; Cupramine) is an example of a mineral-binding or chelating compound that has been standardized for provocative testing and therapeutic monitoring.

First-line comprehensive care: anthropogenic xenobiotics in functional medicine

Penicillamine is being used successfully to slow the progression on the sclerodactyly (see Figure 3).

Scleroderma: a case presentation

But the 68 year-old Teesside granddad admits he's one of the lucky ones - because his medication, Penicillamine, has fought off most of the symptoms.

Ken has got pain relief off to a tea

Other Pb-chelating agents [Ca[Na.sub.2]EDTA, citrate, penicillamine, and 2,3-dimercapto-1-propanol, also known as British AntiLewisite (BAL)] have been shown to increase GI Pb absorption, and in some cases (citrate, penicillamine, and BAL) this has resulted in an increase in body Pb burden (11).

Oral Succimer Decreases the Gastrointestinal Absorption of Lead in Juvenile Monkeys

Through our research, we soon learned that penicillamine, the medication Justin was taking, was very dangerous.

Never Give Up Hope