Significant improvement for hyperkeratosis and
onycholysis, moderate improvement for oil drops, and slight improvement for pitting were observed.
Nail involvement in psoriasis usually is divided into two major groups: (a) signs of involvement of nail matrix including pitting, leukonychia, red spots of the lunula, transverse grooves (Beau's lines), and crumbling of the nail plate and (b) signs of involvement of the nail bed which present as oil-drop discoloration, splinter hemorrhages, subungual hyperkeratosis, and
onycholysis [5].
A characteristic feature of psoriasis of the nails is
onycholysis with a yellowish brownish hue resembling that of an oil spot and caused by elevation of the nail plate by a psoriatic plaque in the nail bed.
The most common clinical signs of SCC of the nail unit are, in decreasing order, subungual hyperkeratosis,
onycholysis, oozing, and nail plate destruction.[sup][2] The tumors are usually growing slowly, simulating other benign conditions, such as chronic paronychia, onychomycosis, pyogenic granuloma, or verruca vulgaris.
Beau's line and
onycholysis were found in 1 patient each.
Nail changes, which may be observed following drug use, include hyperpigmentation,
onycholysis, and onychomadesis.
Nail changes, including nail dystrophy, subungual hyperkeratosis and
onycholysis are common among patients with psoriasis, albeit being less frequent in patients without arthritis (3,20,33).
(2) POPP is considered to be an uncommon subset of psoriatic arthritis that is characterized by psoriatic onychodystrophy,
onycholysis, connective tissue thickening above the distal phalanx as well as specific radiologic changes such as periosteal reaction and bone erosions of the distal phalanges.
We have reported the case of a male patient who developed distal
onycholysis after receiving 100 mg diclofenac and exposure to UV light.
Over-hydration could cause
onycholysis (separation of the nail plate from the nail bed or lifting of the nail).
Allergic contact dermatitis and
onycholysis from hydroxylamine sulphate in colour developer.
In pseudo (apparent) leuconychia, there is involvement of subungual tissue due to
onycholysis or subungual hyperkeratosis or pathology of matrix or nailbed instead of nailplate2.