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The wide variety of drugs in development includes opioid receptor ligands, bradykinin antagonists, mPGES-1 inhibitors, glutamate receptor antagonists, substance P and neurokinin receptor antagonists, norepinephrine transporter inhibitors,P2X2 neuron receptor antagonists and nitric oxide-based analgesics.

Pain Therapeutics Drugs, Companies, Markets, 2028

Desipramine, a potent norepinephrine transporter (NET) inhibitor, blocks the entry of tyramine into cells by NET, thereby preventing hypertensive events in animal models of tyramine overexposure.

A concise guide to monoamine oxidase inhibitors: How to avoid drug interactions: Use these strategies to maximize efficacy and minimize adverse effects when prescribing an MAOI

Sesack, "Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex," Journal of Neuroscience, vol.

Stress Induced Neuroplasticity and Mental Disorders 2018

Biochemically, the active ingredient in Rhopressa, netarsudil, has been shown in Aerie studies to inhibit both Rho kinase and norepinephrine transporter.

FDA Advisory Committee Votes in Favour of Rhopressa (netarsudil ophthalmic solution) 0.02%

In conjunction, the company's preclinical studies have demonstrated that Rhopressa lowers episcleral venous pressure, which contributes half of IOP in healthy subjects; provides an additional mechanism that reduces fluid production in the eye and lowers IOP; inhibits both Rho Kinase (ROCK) and norepinephrine transporter (NET); As well as may have an anti-fibrotic effect on the trabecular meshwork and the potential to increase perfusion of the trabecular meshwork.

Aerie Pharmaceuticals submits NDA to US FDA for Rhopressa 0.02% for treating glaucoma or ocular hypertension

Lack of association between the norepinephrine transporter gene and major depression in a Han Chinese population.

The serotonin transporter gene (triallelic 5-HTTLPR polymorphism) may associate with male depression in Han Chinese population

(31-35) One potential mechanism involves changes in the norepinephrine transporter (NET).

Potential mechanisms of autonomic lnvolvement in subgroups of chronic fatigue syndrome patients

Norepinephrine transporter (NET) plays important role in pathophysiology of many neurodegenerative diseases such as Alzheimer's disease and hyperactivity disorders [93].

Transendothelial transport and its role in therapeutics

[122,123] The norepinephrine transporter (NET) is responsible for the reuptake of norepinephrine into presynaptic neurons, and it is an important factor in the regulation of the noradrenergic system.

Advances in genetic studies of substance abuse in China

Radiolabeled nisoxetine is also used to identify norepinephrine transporter (NET) kinetics and density [14, 16, 17].

High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor

Also, this is what probably happens when methamphetamine, ephedrine, or other similar substances induce dopamine (and other monoamine) release from monoamine neurons primarily via membrane transporters, reversing the dopamine transporter (DAT), norepinephrine transporter (NET), and/or serotonin transporter (SERT) [23-27] and also reversing VMAT vesicular transport [28].

Transport reversal during heteroexchange: a kinetic study